血浆置换联合连续性肾脏替代治疗妊娠期高脂血症性急性胰腺炎的临床观察  

Plasma exchange combined with continuous renal replacement therapy in gestational hyperlipidemic acute pancreatitis

作　　者：更藏尖措 周莉[2] 李文歌[2] 郑郑[3] 

机构地区：[1]青海省第四人民医院急诊科,西宁810000 [2]卫生部中日友好医院肾内科,北京 [3]卫生部中日友好医院妇产科

出　　处：《国际移植与血液净化杂志》2012年第4期25-28,共4页International Journal of Transplantation and Hemopurification

摘　　要：目的观察血浆置换联合连续性。肾脏替代治疗妊娠期高脂血症性急性胰腺炎的临床疗效。方法对6例妊娠期高脂血症性急性胰腺炎患者采用血浆置换联合连续性肾脏替代治疗，观察治疗前、后患者的各项生化指标变化及效果。结果血浆置换联合连续性肾脏替代治疗可以缓解患者的临床症状，降低患者的病死率并能改善预后，是妊娠期高脂血症性急性胰腺炎患者有效地治疗手段之一。6例患者中5例治愈，随访至今无胰腺炎复发。1例死亡（死于多器官功能衰竭）。结论血浆置换联合连续性肾脏替代治疗在高脂血症性急性胰腺炎中有着双重作用，不仅具有显著的降脂作用，还可以祛除体内的炎性介质，阻断系统性炎症反应综合征的发生，从而防止多脏器功能衰竭。Objective To observe effect of plasma exchange （PE） combined with continuous renal replacement therapy （CRRT） treatment of gestational hyperlipidemic acute pancreatitis＇ clinical curative effect. Methods To observe 6 cases of gestational hyperlipidemic acute pancreatitis patients using PE combined with CRRT before and after treatment in patients with various biochemical index change and effect. Results After PE and CRRT treatment, the clinical symptoms can be alleviated, reduce mortality. Impro- ving the prognosis is gestational hyperlipidemic acute pancreatitis patients and effective means of treatment. 5 cases were cured, the follow-up showed no recurrent pancreatitis. 1 patient died, died of multiple organ fai- lure. Conclusion PE combined with CRRT in the treatment of hyperlipidemic acute pancreatitis （HLAP） has a dual role, not only have significant lipid-lowering effect, but also can eliminate in vivo inflammatory mediators, block to occurs the systemic inflammatory response syndrome and prevent multiple organ failure.

关 键 词：高脂血症性急性胰腺炎 血浆置换 治疗结果 

分 类 号：R576[医药卫生—消化系统]