松果体素的节律与阿尔茨海默病  

Circadian Rhythm of Melatonin and Alzheimer′s Disease

作　　者：周江宁[1] 刘雅静[1] 

机构地区：[1]中国科学院脑功能与脑疾病重点实验室 中国科学技术大学生命科学学院,合肥230027

出　　处：《生物化学与生物物理进展》2012年第8期796-803,共8页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)资助项目(2012CB947600)~~

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)患者常伴有生物节律的紊乱,且紊乱的昼夜节律与患者的认知功能损伤显著相关.松果体素水平降低及昼夜节律紊乱发生在AD早期,并与早期病理改变相关.基于松果体素的神经保护作用,给AD患者补充松果体素结合光治疗可以延缓AD认知功能的损伤,至少与已知的抗痴呆药物具有类似的效应.本文系统综述松果体素的节律失调与阿尔茨海默病的关系.There are disturbed circadian rhythm in Alzheimer＇s disease （AD） patients, which is related to the declined cognitive function. Our group has reported that disturbance of circadian rhythm and melatonin level was an early event in the process of AD, which accompanied with the progression of AD neuropathology. The combined treatment with melatonin and light could delay the impairment of AD cognitive function. In the present review, we will discuss the relationship between disturbed melatonin rhythm and AD.

关 键 词：阿尔茨海默病 松果体素 节律紊乱 治疗 

分 类 号：R74[医药卫生—神经病学与精神病学]