血管紧张素转换酶抑制剂治疗阿尔茨海默病的效果  

Effects of angiotensin converting enzyme inhibitors on Alzheimer′s disease

作　　者：储佺兵 苑瑞敏 童玉翠[1] 陈广生[1] 许家佳 张晗[1] 孙永安[2] 

机构地区：[1]马鞍山十七冶医院神经内科,安徽省243000 [2]北京大学第一医院神经内科

出　　处：《江苏医药》2012年第15期1800-1802,共3页Jiangsu Medical Journal

摘　　要：目的观察血管紧张素转换酶抑制剂(ACEI)治疗阿尔茨海默病(AD)痴呆患者的精神行为症状、认知功能损害的效果。方法 52例AD痴呆患者口服盐酸卡托普利治疗12周,采用神经精神科问卷(NPI)评定患者的精神行为症状变化,采用简易智能状态检查量表评定患者的认知功能变化。结果治疗12周后,除情感淡漠外,NPI各项因子得分显著下降(P<0.05),NPI总分下降81.47%(P<0.05);照顾者的苦恼程度也随着患者精神行为症状的改善而降低;治疗前后患者的认知功能无显著性差异(P>0.05)。结论盐酸卡托普利可以明显改善AD痴呆患者的精神行为症状,但对患者的认知功能损害无明显疗效。Objective To observe the effects of hydrochloride captopril, one of angiotensin converting enzyme inhibitors （ACEIs）, on behavioral and psychological symptoms and cognitive impairments of Alzheimer＇ s disease. Methods Fifty-two patients with Alzheimer＇ s disease were treated with captopril for 12 weeks. The neural psychiatric questionnaire（NPI） and the mini-mental state examination（MMSE） were used to evaluate the efficacy and cognitive changes. Results After treated for 12 weeks, the scores of each NPI factor were significantly decreased（P〈0.05） and total scores of NPI decreased by 81.47% （P〈0. 05）. The distress degrees of caregivers of patients decreased while the behavioral and psychological symptoms of patients improved. But the patients showed no cognitive benefits （P〉0. 05 ）. Conclusion Hydrochloride captopril could significantly reduce the psychological and behavioral symptoms without improvement in the cognitive impairments.

关 键 词：阿尔茨海默病 血管紧张素转换酶抑制剂 

分 类 号：R741[医药卫生—神经病学与精神病学]