幽门螺杆菌感染与非口源性口臭关系的研究  

Study on the relationship between helicobacter pylori infection and halitosis without periodontal diseases

作　　者：钮秋亚[1] 徐克群[1] 薛乐宁[1] 谭勇[1] 

机构地区：[1]南京医科大学附属常州市第二人民医院消化科,江苏常州213003

出　　处：《实用临床医药杂志》2012年第11期123-124,共2页Journal of Clinical Medicine in Practice

摘　　要：目的探讨幽门螺杆菌(Hp)感染与非口源性口臭的关系。方法选择无牙周疾病的口臭患者68例,健康对照组70例,进行13C呼气试验检测Hp感染情况;对Hp感染的口臭患者随机分为A、B两组,A组行三联方案根除Hp,B组不予根除Hp治疗,检查两组患者Hp及口臭的根除情况。结果 68例口臭患者的Hp阳性率为64.7%(44/68)。无口臭对照组有23例为Hp阳性,Hp阳性率为32.9%,差异具有统计学意义(P<0.01)。44例口臭患者随机分为两组,A组22例予根除Hp治疗,其中19例根除Hp成功,根除率为86.4%,根除Hp者口臭缓解18例,占94.7%。B组22例未予根除Hp治疗,同期复查口臭,缓解为2例,占9.1%,差异具有统计学意义(P<0.01)。结论幽门螺杆菌感染是非口源性口臭其中一个重要相关因素。Objective To explore the relationship between helicobacter pylori（Hp） infection and halitosis without periodontal diseases.Methods A total of 68 halitosis patients without periodontal diseases and 70 healthy volunteers were included in the study.Hp infection was determined by 13C-urea breath test.Those who got halitosis were divided into groups A and B： Group A received triple therapy to eradicate Hp and group B received no eradication therapy.The changes of halitosis in both groups were observed.Results The positive rate of Hp in halitosis patients was 64.7%（44/68）,which was higher than the 32.9%（23 patients） in the control group（P〈0.01）.The 44 halitosis patients were equally randomized into groups A and B.Twenty-two patients in group A received Hp eradication therapy and 19 were successful with an eradication rate of 86.4%.Eighteen（94.7%） Hp patients had halitosis relieved.Twenty-two patients in group B did not receive Hp eradication therapy.Halitosis was reexamined at the same period.Two patients（9.1%） had symptoms relieved.The difference was statistically significant（P〈0.01）.Conclusion Hp infection might play a causative role in the development of halitosis without periodontal diseases.

关 键 词：幽门螺杆菌 口臭 

分 类 号：R573[医药卫生—消化系统]