家族性腺瘤性息肉病伴发上消化道息肉57例分析  

Upper-gastrointestinal polyps found in cases of familial adenomatous polyposis

作　　者：徐晓东[1] 傅传刚[1] 宋宁[1] 张卫[1] 刘连杰[1] 孟荣贵[1] 于恩达[1] 

机构地区：[1]第二军医大学长海医院普外二科,上海200433

出　　处：《中华普通外科杂志》2012年第8期613-615,共3页Chinese Journal of General Surgery

摘　　要：目的探讨家族性腺瘤性息肉病（familial adenomatous polyposis，FAP）患者伴发上消化道息肉（胃及十二指肠）的发生率、内镜下的表现特征及其病理学特点。方法对上海第二军医大学长海医院2004年1月至2010年6月收治的57例临床诊断为FAP患者采用胃镜、十二指肠侧视镜进行上消化道病变的筛查，并对发现的息肉样病灶进行组织学活检，分析FAP伴胃及十二指肠息肉的发病状况。结果本组57例FAP患者中发生胃内息肉38例，占67％，息肉多数位于胃体和胃窦部，为增生性息肉；十二指肠息肉12例，占21％，其中7例为腺瘤性息肉。结论上消化道息肉是FAP最常见的大肠外病变，胃内息肉多为增生性息肉；而十二指肠可能伴发腺瘤性息肉，属癌前病变。Objective To discuss the incidence, endoscopic manifestion and pathological features of the upper-gastrointestinal polyps （ stomach and deodenum） in FAP patients. Methods During 2004 - 2010 a total 57 FAP patients at Changhai Hospital underwent screening for polyps in upper-gastrointestinal tract by gastroscopy and sideward-viewing duodenoscopy. Biopsies were taken on the polypoid lesions. Results Gastric polyps were found in 38 patients （67%）. Most polyps were located at gastric body and antrum, the pathologic diagnosis was hyperplastic. Duodenal polyps were found in 12 patients （21%） including 7 cases of adenomatous polys. Conclusions Upper- gastrointestinal polyps are the most common extra-colonic manifestion in FAP. Most stomach polyps are located at gastric body and antrum and are hyperplastic. Polyps at duodenum may be adenomatous, which is a precusor of carcinoma.

关 键 词：腺瘤息肉病 结肠 息肉 病理学 临床 

分 类 号：R735[医药卫生—肿瘤]