超声探测甲状腺结节钙化对甲状腺癌的诊断价值  

Value of ultrasound detection of calcification in the diagnosis of thyroid carcinoma

作　　者：江将[1] 张平[1] 王志宏[1] 董文武[1] 贺亮[1] 张浩[1] 

机构地区：[1]中国医科大学附属第一医院普通外科,沈阳110001

出　　处：《中华普通外科杂志》2012年第8期623-626,共4页Chinese Journal of General Surgery

基　　金：辽宁省“百千万人才工程”资助项目（2010921070）;辽宁省教育厅创新团队资助项目（LT2010102）

摘　　要：目的探讨超声探测甲状腺结节钙化对甲状腺癌的诊断价值。方法回顾性分析我院3924例甲状腺疾病患者的超声资料和病理结果，探讨钙化、微小钙化、粗大钙化和边缘环状钙化与甲状腺癌的关系，单发结节伴钙化和多发结节伴钙化与甲状腺癌的关系以及不同年龄组钙化与甲状腺癌的关系。结果甲状腺良性疾病钙化和微小钙化的发生率分别为32．05％和6．50％，甲状腺癌则为80．07％和51．53％，甲状腺癌钙化和微小钙化的发生率高于良性疾病（P〈0．01）；单发结节和多发结节伴钙化的恶性率分别为53．31％和22．16％，伴微小钙化的恶性率则分别为74．12％和47．92％，单发结节伴钙化和伴微小钙化的恶性率均要高于多发结节，差异有统计学意义（P〈0．01）；〈70岁患者钙化的恶性率随年龄增加逐渐下降（P〈0．05）；微小钙化的恶性率在44岁及以下年龄组〉44岁以上年龄组（P〈0．01）。结论钙化和微小钙化是甲状腺癌的高危因素，单发结节和年轻患者的钙化和微小钙化的恶性率更高。Objective To investigate the clinical value of sonographic detection for calcification in diagnosis of thyroid carcinoma. Methods Clinical data of 3924 thyroid disease patients examined by uhrasonography and pathology at First Hospital of China Medical University were retrospectively reviewed to investigate the relationship between calcification, microcalcification, macrocalcification and peripheral calcification with thyroid carcinoma, the relationship between solitary nodule with calcification and multiple nodules with calcification with thyroid carcinoma and the relationship between calcification with thyroid carcinoma in different age groups. Results The incidences of calcification, microcalcification in malignant and benign thyroid patients were 32. 05%, 6. 50% and 80.07%, 51.53%, the incidences of calcification and microcalcification were significantly higher in malignant group than in benign group （P 〈 0. 01 ）. The incidence of carcinoma in solitary nodules with calcification was 53.33% while it was 22. 2% in muhiple nodule group, the incidence of carcinoma in solitary nodules with calcification was significantly higher than that in multiple nodules （P 〈 0.01 ）. The incidence of carcinoma in solitary nodules with microcalcification was 74. 1% while in muhiple nodule group it was 47.9%, the incidence of carcinoma in solitary nodules with microcalcification was significantly higher than that in multiple nodules （ P 〈 0. 01 ）. The incidence of carcinoma younger than 70 years of age with caicification in different age groups was significantly different （P 〈 0. 05）. In 40 and younger age group, the incidence of carcinoma with microcaicification was higher than that in over 44 years group （ P 〈 0. 01 ）. Conclusions Calcification or microcalcification is considered to be a risk factor of thyroid carcinoma. Solitary nodules with calcification or microcalcification found in younger patients were more likely to coexist with thyroid carcinoma.

关 键 词：甲状腺肿瘤 超声检查 发病年龄 钙化 

分 类 号：R736.1[医药卫生—肿瘤]