351例胃癌术后患者的预后因素分析  

Analysis on Prognostic Factors of 351 Patients with Gastric Cancer Underwent Gastrectomy

作　　者：王蓓[1] 吕成余[1] 谢洪虎[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)普外科,江苏南京210006

出　　处：《中国普外基础与临床杂志》2012年第7期743-748,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：南京市医学科技发展资金资助项目(项目编号:YKK09066);南京市科技计划项目(项目编号:201106016)~~

摘　　要：目的探讨胃癌术后影响胃癌患者生存的因素。方法将2004年1月至2009年12月期间在笔者所在医院行手术治疗并获随访的351例胃癌患者作为研究对象,对其临床病理资料及随访资料进行单因素和多因素分析。结果单因素分析显示患者年龄以及肿瘤部位、T分期、N分期、TNM分期和分化程度与预后有关(P<0.05);多因素分析显示肿瘤部位、T分期、N分期和术后化疗是影响胃癌术后生存率的独立因素(P<0.05)。结论肿瘤部位、浸润深度、淋巴结转移率及术后辅助化疗是影响胃癌术后生存的重要因素。对于有淋巴结转移或处于TNMⅢ期的胃癌患者,术后化疗可以提高其生存率。Objective To investigate the prognostic factors related to long-term survival atter gastrectomy. Methods A total of 351 patients with gastric cancer who underwent gastrectomy were successfully followed-up in our hospital had been selected from January 2004 to December 2009. The clinicopathological and follow-up data were studied by univariate and multivariate analysis. Results The age, location of tumors, T stage, N stage, TNM stage, and differentiation were related with postoperative survival of patients with gastric cancer by using univariate analysis （P〈 0.05）. By using multivariate analysis, location of tumors, T stage, N stage, and chemotherapy were independent prog- nostic factors （P〈 0. 05）. Conclusions Location of tumors, depth of minor invation, lymph node metastasis, and chem- otherapy were independent prognostic factors for gastric cancer patients who underwent gastrectomy. Chemotherapy after surgery could increase the survival rate of gastric cancer patients with lymph node metastasis or in TNM stage Ⅲ.

关 键 词：胃癌 预后因素 生存率 

分 类 号：R735.2[医药卫生—肿瘤]