缺血性脑血管病颈动脉颅外段不稳定斑块形成相关危险因素分析  

Analysis of related risk factors of unstable plaques in extracranial carotid arteries in patients with ischemic cerebrovascular diseases

作　　者：刘静[1] 赵婷婷[1] 毕作宾[1] 

机构地区：[1]山东大学齐鲁医院桓台分院神经内科三病区,256400

出　　处：《中国医师进修杂志》2012年第21期26-29,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨缺血性脑血管病（ICVD）患者颈动脉颅外段不稳定斑块形成的相关危险因素。方法共纳入208例行颈部彩色超声检查有颈动脉颅外段斑块形成的ICVD患者，根据超声表现分为不稳定斑块组（75例）及稳定斑块组（133例）。所有患者均记录相关疾病病史及ICVD的传统危险因素。先以单因素非条件Logistic回归分析筛选出有统计学意义的危险因素，再应用多因素非条件Logistic回归分析颈动脉颅外段不稳定斑块形成的独立危险因素。结果单因素非条件Logistic回归分析显示，男性、高血压病史、糖尿病病史、吸烟与颈动脉颅外段不稳定斑块形成呈正相关（P〈0．01或〈0．05），高密度脂蛋白胆固醇（HDL-C）与颈动脉颅外段不稳定斑块形成呈负相关（P〈0．01）；两组在冠心病病史、生活规律、家族高血压病史、饮酒、家族卒中病史、低密度脂蛋白胆固醇方面比较差异无统计学意义（P〉0．05）。多因素非条件Logistic回归分析显示，男性、高血压病史、糖尿病病史及吸烟是颈动脉颅外段不稳定斑块形成的独立危险因素（OR值分别为2．33、7．16、6．15、2．28，P〈0．01）；而HDL-C是颈动脉颅外段不稳定斑块形成的保护因素（OR值为0．84，P〈0．01）。结论ICVD患者颈动脉颅外段不稳定斑块形成的独立危险因素是男性、高血压病史、糖尿病病史及吸烟。而HDL-C是ICVD患者颈动脉颅外段不稳定斑块形成的保护因素。对具有危险因素的患者进行必要的干预具有重要的意义。Objective To investigate the related risk factors of unstable plaques in extracranial carotid arteries in patients with ischemic cerebrovascular diseases （ICVD）. Methods Two hundred and eight ICVD patients were enrolled and plaques in extracranial carotid arteries were detected by carotid color ultrasound. All the patients were divided into unstable plaque group （75 cases） and stable plaque group （ 133 cases） according to the ultrasound performance. Related disease history and the traditional risk factors of ICVD were recorded. The risk factors with statistical significance were screened out by univariate non- conditional Logistic regression analysis,and then the independent risk factors of unstable plaques in extracranial carotid arteries were analyzed by multivariate non-conditional Logistic regression analysis. Results Univariate non-conditional Logistic regression analysis showed that male, history of hypertension, history of diabetes,smoking were positively correlated with the formation of unstable plaques in extracranial carotid arteries（P 〈 0.01 or 〈 0.05）. High density lipoprotein cholesterol （HDL-C） was negatively correlated with the formation of unstable plaques in extracranial carotid arteries （P 〈 0.01 ）. There were no statistical significance in history of coronary heart disease, law of life, family history of hypertension, drinking, family history of stroke and low density lipoprotein cholesterol between two groups （P 〉0.05）. Multivariate non-conditional Logistic regression analysis showed that male, history of hypertension, history of diabetes and smoking were the independent risk factors of the formation of unstable plaques in extracranial carotid arteries （OR = 2.33,7.16,6.15,2.28 ,respectively,P 〈 0.01 ）. And HDL-C was the protection factor of the formation of unstable plaques in extracranial carotid arteries （OR = 0.84,P 〈 0.01 ）. Conclusions The independent risk factors of the formation of unstable plaques in extracranial carotid arteries in pati

关 键 词：颈动脉 颈动脉狭窄 超声检查 多普勒 彩色 危险因素 脑缺血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]