用近红外光拓扑图技术短期预测脑梗塞  

SHORT-TERM PREDICTION OF CEREBRAL INFARCTION WITH NEAR INFRARED SPECTROSCOPY TOPOGRAPHY

作　　者：陈卫国[1] 李鹏程[1] 骆清铭[1] 卢广[2] 胡波[3] 

机构地区：[1]华中理工大学生物医学光子学研究所,激光技术国家重点实验室,武汉430074 [2]中国科学院武汉分院磁共振和原子,分子物理国家重点实验室,武汉430074 [3]同济医科大学附属协和医院神经内科,武汉430030

出　　处：《光子学报》2000年第8期673-677,共5页Acta Photonica Sinica

基　　金：国家自然科学基金资助项目 !(批准号 :3 9770 2 2 8)

摘　　要：本研究用近红外光大脑拓扑图技术 ( near- infrared cerebral topography,NIRStopography) ,对大鼠大脑中动脉线栓梗塞模型的皮层缺血部位进行定位成象 .我们利用氧合血红蛋白和去氧血红蛋白对近红外光的吸收峰值波长分别为 850 nm和 760 nm的原理 ,制作了 NIRS拓扑仪 .分别用 NIRS拓扑仪、磁共振成象和解剖样本染色对 1 0只 SD雄性大鼠大脑皮层缺血部位进行成象 .结果表明 ,NIRS拓扑图所显示的皮层缺血面积与磁共振图象及解剖样本所显示的皮层缺血面积的相关系数分别为 0 .82 ( p<0 .0 5)和 0 .89( p<0 .0 1 ) .A dual wavelength (760nm and 850nm) Near Infrared Spectroscopy (NIRS) that reflected total hemoglobin concentration changes in measurement area was constructed and relative software was programmed.It is used the NIRS topography to localize the cortical ischemia focus,which had significant blood supplement reduction on the rat′s middle cerebral artery occlusion model.The cortical ischemia area NIRS topography showed was compared with that of Magnetic Resonance Imaging (MRI) and of anatomical sample for same rat.The results showed that there was a significant correlation among NIRS topography,MRI (r=0.82,p<0.05) and anatomical sample (r=0.89,p< 0.01) for same cortical ischemia area.

关 键 词：近红外光谱 拓扑图 脑梗塞 预测 实时 

分 类 号：R743.33[医药卫生—神经病学与精神病学]