纳米药物载体结合分子靶向在肿瘤化疗中的应用  

Applications of Nanocarriers with Tumor Molecular Targeted in Chemotherapy

作　　者：丁辉[1] 张松[1] 刘新利[1] 

机构地区：[1]山东轻工业学院食品与生物工程学院、山东省微生物工程重点实验室,济南250353

出　　处：《化学通报》2012年第7期621-627,共7页Chemistry

基　　金：山东省自然科学基金项目(ZR2011CQ006);山东省博士后创新项目专项资金(200903077)资助

摘　　要：纳米技术与肿瘤治疗中的化学疗法相结合具有广阔的应用前景,应用纳米技术设计药物载体递送化疗药物已经成为当前人类攻克肿瘤研究的一个重要手段。纳米药物载体与肿瘤靶向在化疗方面的应用,能够有效改善化疗药物水溶性和稳定性,提高药物利用率和抗肿瘤活性,降低对机体正常细胞组织的毒副作用,克服多药耐药性问题,进而提高肿瘤化疗效果和促进肿瘤化疗的发展进步。本文着重综述纳米药物载体系统及其靶向策略方面的研究现状与进展,并探讨纳米技术与化疗相结合攻克肿瘤的应用前景。Nanotechnology has received considerable attention in the revolutionize tumor therapy especially chemotherapy. The nanocarriers of chemotherapeutic have become an important tool to overcome tumor. Drug delivery system and molecular tumor targeting based on nanotechnology can effectively improve the water solubility and stability, enhance drug utilization and anti-tumor activity, reduce the normal tissue toxicity and solve the problem of multi-drug resistance, and thus contribute significantly to the development and progress of chemotherapy. This review focuses on the research status quo and progress in nanocarriers of the drugs and the tumor targeting strategies. And the application prospect of nanotechnology in chemotherapy is investigated.

关 键 词：肿瘤 化疗 纳米技术 药物载体系统 肿瘤靶向 

分 类 号：R730.5[医药卫生—肿瘤]