养血化瘀止血合抗凝抗纤溶治疗恶性肿瘤并发弥散性血管内凝血49例  

Therapeutic Efficacy of Traditional Chinese Medicines with Blood-nourishing,Blood stasis-removing,and Hemostatic Effects Combined with Anticoagulant and Antifibrinolytic Drugs in 49 Malignant Tumor Cases with Disseminated Intravascular Coagulation

作　　者：向生霞[1] 潘燕[1] 丁晖[1] 汤丽萍[1] 滕昊岐[1] 刘海[1] 

机构地区：[1]四川省中西医结合医院内五科,四川成都610041

出　　处：《安徽中医学院学报》2012年第4期31-34,共4页Journal of Anhui Traditional Chinese Medical College

摘　　要：目的观察养血化瘀止血合抗凝抗纤溶治疗肿瘤并发弥散性血管内凝血(disseminated intravascular coagulation,DIC)的临床疗效。方法将确诊的肿瘤DIC患者89例随机分为治疗组49例、对照组40例。对照组在积极治疗原发病的基础上给予抗凝抗纤溶治疗,观察组在对照治疗基础上给予活血化瘀止血中药治疗。观察两组临床症状改善时间和两组临床疗效,检测并比较两组治疗前后血小板(platelet count,PLT)计数、纤维蛋白原(fibrinogen,Fbg)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶原时间(prothrombin time,PT)、纤维蛋白(原)降解产物(fibrin degradation products,FDP)、D-二聚体。结果观察组临床症状改善时间显著低于对照组(P<0.05);观察组PLT、Fbg、APTT、PT、FDP较对照组明显改善(P<0.05);观察组和对照组总有效率分别为69.4%、42.5%,其差异有统计学意义(P<0.05)。结论养血化瘀止血合抗凝抗纤溶治疗能够明显改善恶性肿瘤DIC患者的凝血纤溶指标和提高临床疗效。Objective To evaluate the therapeutic efficacy of traditional Chinese medicines with blood-nourishing, blood stasis-removing,and hemostatic effects combined with anticoagulant and antifibrinolytic drugs in trea- ting disseminated intravascular coagulation （DIC） complicating malignant tumor. Methods A total of 89 confirmed malignant tumor cases with DIC were randomly diviced into treatment group （n=49） and con- trol group （n：40）. Both groups received anticoagulant and antifibrinolytic treatment on the basis of thera py of primary disease, and, additionally, the treatment group received treatment using traditional Chinese medicines with blood-nourishing, blood stasis-removing, and hemostatic effects. The time of improvement in symptoms was measured in each group. The therapeutic efficacy was evaluated based on piatelet count （PLT）, fibrinogen （Fbg）, activated partial thromboplastin time （APTT）, prothrombin time （PT）, fibrin degradation products （FDPs）, and D-dirner. Results The treatment group had a significantly shorter time of improvement in symptoms than the control group （P^0.05）. Compared with the control group, the treatment group showed significant improvement with respect to PLT, Fbg, APTT, PT, and FDPs（P~ 0.05）. The overall response rate was significantly higher in the treatment group than that in the control group （69.4% vs. 42.5%, P〈0.05）. Conclusion Traditional Chinese medicines with blood-nourishing, blood stasis-removing, and hemostatic effects combined with anticoagulant and antifibrinolytic drugs can significantly improve the indices of coagulation and fibrinolysis and show better therapeutic efficacy in ma- lignant tumor patients with DIC.

关 键 词：弥散性血管内凝血 养血 化瘀 止血 抗凝治疗 抗纤溶治疗 

分 类 号：R730.1[医药卫生—肿瘤]