E838对小鼠骨髓细胞染色体的辐射防护作用  

The protective effects of the E838 against radiation-induced chromosomal injury in mice

作　　者：王月英[1] 吴红英[1] 叶翔[2] 李德冠[1] 王小春[1] 张恒[1] 路璐[1] 孟爱民[1] 

机构地区：[1]中国医学科学院北京协和医学院放射医学研究所天津市分子核医学重点实验室,天津300192 [2]天津迈达医学科技有限公司,天津300384

出　　处：《中国生化药物杂志》2012年第4期441-442,共2页Chinese Journal of Biochemical Pharmaceutics

基　　金：国家973重大专项(2011CB964800-G);国家自然科学基金(81072237);天津市重点基金(11JCZDJC19100);天津市科技计划项目(10SYSYJC28200)

摘　　要：目的探讨E838对γ射线照射小鼠骨髓细胞染色体损伤的防护作用。方法将615小鼠,随机分为对照组、辐射对照组、E838组、炔雌三醇(EE3)组。E838组和EE3组分别腹腔注射E838和EE3,另两组给予等体积茶油,第3次给药24 h后进行剂量为1.5 Gy的137Csγ射线全身照射,观察其骨髓细胞染色体畸变率。结果 E838组、EE3组骨髓细胞染色体畸变与辐射对照组比较差异有统计学意义(P<0.01),E838组畸变细胞与EE3组比较差异有统计学意义(P<0.05)。结论 E838可降低辐射诱发的骨髓细胞染色畸变细胞数,对骨髓细胞染色体具有一定的辐射防护作用。Purpose To investigate the protective effects of the E838 against radiation induced chromosomal injury in mice.Methods 20 male 615 mice were divided into four groups randomly：control,total body irradiation exposure（IR）only,IR＋ E838 and IR＋EE3 groups,5 mice each group.Treated groups either accepted E838 or EE3 intraperitoneally for 3 days,after treatment 24 for hours mice were exposed to a dose of 1.5 Gy 137Cs γ irradiation.The chromosome aberration rate of bone marrow cells was observed.Results The chromosome aberration rate of IR＋E838 and IR＋EE3 groups had significant difference compared with the IR groups（P〈0.01）.There was difference beteen the IR＋ E838 and IR＋EE3 groups（P〈0.05）.Conclusion E838 could reduce the rate of radiation-induced chromosome aberration,and had protective effects against radiation induced chromosomal damage of bone marrow cells.

关 键 词：E838 骨髓细胞 染色体畸变 辐射防护 

分 类 号：R962[医药卫生—药理学]