血红素铁改善缺铁性贫血效果观察  

Effect of the heme iron supplement on improving nutritional anemia in women

作　　者：陈炜林[1] 胡余明[1] 李梓民[1] 

机构地区：[1]湖南省疾病预防控制中心,湖南长沙410005

出　　处：《中国食品卫生杂志》2012年第4期309-311,共3页Chinese Journal of Food Hygiene

摘　　要：目的了解血红素铁对缺铁性贫血的影响。方法将符合贫血诊断的女性108人随机分为血红素铁组和对照组,并分别给予血红素铁和安慰剂,连续服用45 d,服用开始前和服用结束时对受试者进行膳食营养调查、体格检查和血液生化指标的检测并进行统计学分析。结果血红素铁组血红蛋白的含量由试验前的(106.43±10.48)g/L上升到(117.34±10.25)g/L,平均升高了10.91 g/L(服用前后配对t检验,P<0.05,服用后与对照组t检验,P<0.05);红细胞游离原卟啉的含量由(942.15±96.34)μg/L下降为(820.53±109.95)μg/L(服用前后配对t检验,P<0.05,服用后与对照组t检验,P<0.05);试验组血清铁蛋白的含量由试验前的(25.19±6.71)ng/ml上升到(25.40±6.69)ng/ml,(服用前后配对t检验,P>0.05)。结论血红素铁对缺铁性贫血具有一定的改善作用。并对受试者健康无不良影响。Objective To investigate the improvement of nutritional anemia in women treated by heme iron supplement. Methods A total of 108 female subjects with nutritional anemia （ Hb 〈 120g/L） were randomly divided into a study group receiving heme iron for 45 days and a control group. Dietary survey, physical examination and blood biochemical examination were carried before and after the trial. Results Hemoglobin levels in the study group increased from （106.43±10.48）g/L to （117.34±10.25）g/L （ P 〈0. 05 ）. There were significant differences between the study group and control group after treatment （P 〈 0. 05 ）. The levels of free erythrocyte protophorphyrin （FEP） in the study group dropped from （942.15±96.34）μg/L to （820.53±109.95）μg/L （ P 〈 0.05 ） , while no significant change of serum ferritin （SF） in the study group from （25.19±6.71）ng/ml to （25.40±6.69）ng/ml （P〉0.05）. Conclusion The heine iron supplement is effective in the treatment of nutritional anemia in women with no serious side effect.

关 键 词：血红素铁 缺铁性贫血 血红蛋白 血清铁蛋白 游离原卟啉 

分 类 号：R556[医药卫生—血液循环系统疾病]