纳洛酮联合BiPAP治疗慢性阻塞性肺疾病合并早期肺性脑病的临床价值  

Clinical values of BiPAP ventilation combined naloxone in the treatment of patients with COPD combined early pulmonary encephalopathy

作　　者：李海燕[1] 

机构地区：[1]河南洛阳市中心医院呼吸内科,洛阳471000

出　　处：《中国实用神经疾病杂志》2012年第14期19-21,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的研究双水平无创正压通气(BiPAP)联合纳洛酮在慢性阻塞性肺疾病合并早期肺性脑病的临床价值。方法将我院近年来呼吸重症监护室收治的48例慢阻肺呼吸衰竭合并早期肺性脑病患者随机分为2组,对照组采用双水平无创正压通气及常规治疗,治疗组采用双水平无创正压通气联合纳洛酮及常规治疗。结果治疗组神志恢复时间及血气改善时间、有创呼吸机使用率明显低于对照组。结论双水平无创气道正压通气联合纳洛酮治疗慢性阻塞性肺疾病合并早期肺性脑病可以缩短血气改善时间,促进肺性脑病患者神志恢复,降低患者的有创呼吸机使用率,扩展无创正压通气的应用范围。Objective To investigate the clinical values of non-invasive hi-level positive pressure ventilation（BiPAP）combined with naloxone in chronic obstructive pulmonary disease patients with early pulmonary encephalopathy. Methods Total 48 patients with COPD combined with early pulmonary encephalopathy in our hospital in recent years were randomly divided into treatment group and control group. The treatment group was treated with BiPAP, as well as conventional therapeutic manage- ments and naloxone administration, whereas, 24 controls only received BiPAP and conventional intervention. Results There was significant difference between the two groups. There was faster recovery of consciousness and improvement in blood gas a- nalysis in the treatment group. The tracheal intubation rate of treatment group was lower than that of control group. Conclu- sion Non-invasive hi-level positive pressure ventilation combined with naloxone in the treatment of chronic obstructive pulmo- nary diseases with early pulmonary encephalopathy may shorten the blood gas improvement, promote consciousness recovery, decrease the tracheal intubation rate and extend the scope of application of noninvasive positive pressure ventilation.

关 键 词：双水平无创正压通气 纳洛酮 早期肺性脑病 气管插管率 

分 类 号：R747.9[医药卫生—神经病学与精神病学]