高同型半胱氨酸血症对急性脑梗死短期预后的影响  

The influence of homocysteinemia on the recent prognosis of acute cerebral infarction

作　　者：李建新[1] 杜婴[1] 李柱一[1] 张巍[1] 苗建亭[1] 

机构地区：[1]第四军医大学唐都医院神经内科,陕西西安710038

出　　处：《中风与神经疾病杂志》2012年第7期651-653,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨高同型半胱氨酸血症(HHcy)与急性脑梗死患者短期预后之间的关系。方法测定165例急性脑梗死患者空腹血浆Hcy浓度,将患者分为HHcy组和非HHcy组,并在其入院时和治疗14d后进行改良Rankin量表(MRS)评分。结果入院时非HHcy组和HHcy组患者MRS评分中生活自理(MRS评分≤2分)人数和不能自理(MRS评分≥3分)人数的百分比之间无统计学差异(P>0.05),经相同药物治疗14d后,非HHcy组患者中生活自理人数的百分比较HHcy组患者显著升高(P<0.01),不能自理人数的百分比较HHcy组患者显著降低(P<0.01),非HHcy组患者中生活不能自理得到改善人数的百分比较HHcy组患者也显著升高(P<0.01)。结论HHcy组急性脑梗死患者的短期预后比非HHcy组差,降低HHcy对于缺血性脑血管病具有重要的预防和治疗意义。Objective To discuss the influence of homocysteine （HHcy） on the recent prognosis of acute cerebral in- farction. Methods We measured the plasma Hcy of 169 patients with acute cerebral infarction, and divided them into HHcy group and non-HHcy group, then estimated the Modified Rankin Scale （MRS）of the patients on admission and after 14-day treatment. Results The MRS scores between HHcy and non-HHcy group had no significant difference on admis- sion（ P 〉 0.05 ）. After M-day treatment, the percentage of patients with daily life ability（ scores of MRS ≤ 2 ）in non-HHcy group was higher than that in HHcy group （ P 〈 0.05 ）, the percentage of patients without daily life ability （ scores of MRS ≥ 3 ）in non-HHcy group was lower than that in HHcy group （P 〈 0.05 ）, and the percentage of patients resuming daily life a- bility in non-HHcy group was also higher than that in HHcy group（P 〈 0.05 ）. Conclusions HHcv is harmful to the re-cent rehabilitation of the patients with acute cerebral infarction, and reducing HHcy is important for prevention and treatment of ischemic cerebrovascular diseases.

关 键 词：高同型半胱氨酸血症 脑梗死 预后 

分 类 号：R743[医药卫生—神经病学与精神病学]