乳腺神经内分泌癌四例临床病理分析  

Clinicopathologic analysis of 4 cases of breast neuroendocrine carcinoma

作　　者：张晓申[1] 潘凌霄[1] 叶熹罡[1] 林晓明[1] 陈伦[1] 郑文博[1] 

机构地区：[1]广州医学院第一附属医院乳腺外科,广东广州510000

出　　处：《海南医学》2012年第15期135-137,共3页Hainan Medical Journal

摘　　要：目的探讨乳腺神经内分泌癌的临床与病理特点。方法回顾性分析2009年12月至2011年12月广州医学院附属第一医院收治的4例乳腺神经内分泌癌病例的临床与病理特点。结果免疫组织化学检测结果提示：突触素及神经元特异性稀醇酶的阳性率为100％；嗜铬颗粒蛋白A、雌激素受体及孕激素受体的阳性率为25．0％；CerbB2的阳性率为50．0％。随访时间为2～19个月（中位随访时间为9个月），远处转移率为25．0％（肺部转移），无瘤生存率为75．0％。结论乳腺神经内分泌癌是罕见的乳腺恶性肿瘤之一，合理治疗有助于提高疾病的预后情况，今后还需要大样本量的长期随访试验对其生物学特性进一步研究。Objective To explore clinical and pathological features of breast neuroedocrine carcinomas （NEC）. Methods The clinical and pathological features of 4 cases with breast NEC admitted in the First Affiliated Hospital of Guangzhou Medical College from Dec. 2009 to Dec. 2011 was analyzed retrospectively. Results The av- erage age of onset was 56 years for the 4 patients, with the mean size of tumors of 6.0 cm. Modified radical resection of breast carcinoma were performed in all the patients. The morphological types of these tumors were solid carcinoma （3 cases） and large cell carcinoma （i case）. In all cases the tumor ceils were stained positively with Syn and NSE （100%）. 2 cases （50.0%） were positive for CerbB2, and 1 case （25.0%） was positive for CgA, ER and PR. All the pa- tients were followed up for 2-19 months, with a median of 9 months. The rate of distant metastasis was 25.0%, and the tumor-free survival rate was 75.0%. Conclusions Breast NEC is a rare breast carcinoma. Rational treatment is of great value to improve the survival rate of patients. The biological characters of the disease need to be investigated by studies with longer follow-up and large sample size.

关 键 词：神经内分泌癌 乳腺肿瘤 病理 临床 

分 类 号：R739.4[医药卫生—肿瘤]