喉癌前病变中医证候及四诊特征初步研究  

Pilot Study on Chinese Medicine Pattern/Syndrome and the Characteristics of Four Diagnostic Methods for Laryngeal Precancerous Lesions

作　　者：卢标清[1] 李云英[2] 孙一帆[1] 周小军[1] 李少华[1] 陈子清[1] 郭亿莲[1] 伍映芳[2] 

机构地区：[1]广州中医药大学附属中山医院,广州中山528400 [2]广州中医药大学附属广东省中医院,广州广东510120

出　　处：《世界中西医结合杂志》2012年第7期579-582,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目(No.30873288);中山市科技计划项目(No.2010A019)

摘　　要：目的通过临床调查探讨喉癌前病变的中医证候及四诊特点,为喉癌前病变的中医药防治及研究提供参考和思路。方法采用流行病学横断面调查方法,对88例喉癌前病变、100例声带息肉及60例喉癌患者的中医证候及四诊资料进行采集分析。结果在声带息肉→喉癌前病变→喉癌的病情进展过程中,中医证候演变特点:以痰瘀为主线,证候由单一向证候兼杂发展,最终出现痰瘀热毒、气阴两虚等多种证候因素兼杂的情况。舌象变化特点:随着病情的发展变化,舌象可由正常的淡红舌为主,向暗红舌、红绛舌、紫舌等发展;舌苔由淡白、白腻向薄黄、黄腻到黄老厚腻变化发展;舌边瘀斑瘀点及舌下静脉曲张的情况更普遍。结论痰瘀是喉癌前病变的基本病因病机,贯穿于喉癌前病变发生发展的始终。Objective To clinically investigate and explore the Chinese medicine pattern/syndrome and the characteristics of the four diagnostic methods of laryngeal precancerous lesions so as to provide the references and thinking approaches to the prevention,treatment as well as the research of laryngeal precancerous lesions with traditional Chinese medicine.Methods The cross-sectional investigation of epidemiology was adopted to collect and analyze the Chinese medicine pattern/syndrome and the characteristics of four diagnostic methods for 88 cases of laryngeal precancerous lesions,100 cases of vocal cord polyp and 60 cases of laryngocarcinoma.Results In the sickness progression,vocal cord polyp → laryngeal precancerous lesions → laryngocarcinoma,the characteristics of the evolution of the Chinese medicine pattern/syndrome indicated：The phlegm stasis pattern/syndrome was essential and the disorders developed more and more complicated.Finally the mixed pattern/syndrome occurred,such as phlegm stasis mixed with heat toxin,and deficiency of qi and yin.The characteristics of tongue conditions：With the development of the disorders,the normal light red tongue was the common one,but the tongue developed to be dark red,deep red or purplish.The tongue coating could be white or white sticky,got thin yellow or yellow sticky,finally got yellow,rough,thick and sticky.It was common to see ecchymosis and petechia on the border of tongue as well as sublingual varices.Conclusion The phlegm stasis is the basic etiology and pathogenesis of laryngeal precancerous lesions and it runs through the whole development of the disorders.

关 键 词：喉癌前病变 中医四诊 证候 临床调查 

分 类 号：R734[医药卫生—肿瘤]