高危型人乳头瘤病毒检测对196例宫颈上皮内瘤变的诊断价值  

The value of detecting high risk type human papillomavirus DNA in diagnosing of 196 cases of cervical intraepithelial neoplasia

作　　者：孙波[1] 邱雪杉[1] 

机构地区：[1]中国医科大学基础医学院病理学教研室,辽宁沈阳110001

出　　处：《延边大学医学学报》2012年第2期139-141,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]明确高危型人乳头瘤病毒基因(HR-HPV DNA)检测在诊断宫颈上皮内瘤变(CIN)中的意义.[方法]选取196例进行HPV DNA检测并经组织学诊断为CIN的患者资料进行分析.[结果]HR-HPV DNA在CINⅠ,CINⅡ,CINⅢ级中的阳性表达率分别为88.63%(39/44),90.00%(36/40),93.75%(105/112),三者之间差异具有统计学意义(P<0.05);且HR-HPV的阳性表达率随着宫颈病变的级别上升呈逐渐增高的趋势.[结论]HR-HPV DNA检测对CIN诊断有重要价值.OBJECTIVE To determine the significance of detecting high risk type human papillomavirus（HR-HPV） DNA in diagnose of cervical intraepithelial neoplasia（CIN）.METHODS 196 cases were selected from hospital to detect the HPV DNA,and the data of patients with CIN were analyzed.RESULTS HR-HPV DNA positive rates in CINⅠ,CINⅡ,CINⅢ were 88.63%（39/44）,90.00%（36/40） and 93.75%（105/112）,respectively,and the difference was statistical significance in 3 groups（P〈0.05）.And the greater risk of cervical lesions were,the higher HR-HPV DNA positive rates were.CONCLUSION HR-HPV detection plays an important role in diagnosis of CIN.

关 键 词：宫颈上皮内瘤样病变 乳头状瘤病毒 人 诊断技术 妇产科 

分 类 号：R365[医药卫生—病理学]