CD2^+急性早幼粒细胞白血病的临床特点分析  

The analysis of clinical characteristics of acute promyelocytic leukemia with CD2 positive

作　　者：耿英华[1] 周黎黎[1] 李骏[1] 胡忠利[1] 朱俊锋[1] 杨艳丽[1] 

机构地区：[1]蚌埠医学院第一附属医院血液科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2012年第8期908-910,共3页Journal of Bengbu Medical College

基　　金：安徽省卫生厅医学科研课题资助项目(2010C082)

摘　　要：目的:探讨CD2+急性早幼粒细胞白血病(APL)的临床特点。方法:采用流式细胞术(FCM)对19例APL的免疫表型进行检测,根据检测结果分为CD2+组及CD2-组,对2组的临床表现、实验室检查、治疗效果等方面进行比较。结果:19例患者中,CD2+4例,CD2-15例;CD2+组发病时外周血WBC高于CD2-组(P<0.05),纤维蛋白原浓度降低(P<0.05),而2组在发病时血小板计数和治疗达到完全缓解时间差异均无统计学意义(P>0.05);4例CD2+APL患者均伴有CD34表达,治疗后均完全缓解;15例CD2-APL患者中,伴有CD34表达者1例,治疗完全缓解14例。结论:CD2+APL病例发病时往往伴有高WBC,具有更高的并发严重出血的风险,可作为APL的预后不良指标及微小残留病变监测指标。Objective： To explore the clinical characteristics of acute promyelocytic leukemia （APL） with CD2 ^＋. Methods： The immunophenotype of 19 cases with APL were detected by flow cytometry. All cases were divided into CD2^＋ and CD2^- group according to the results of immunophenotype. The clinical performance, laboratory examination and therapeutic effects of two groups were analysed. Results：Compared with 15 cases with CD2^- , the higher WBC counts and lower fibrinogen contents of 4 cases with CD2 ^＋ were observed（P 〈 0.05 ） , and the differences of platelet counts and CR time of two groups had no statistical significance （ P 〉 0.05 ）. The CD34 expressions were detected in all 4 cases with CD2^＋ , which could complete remission after treatment. The CD34 expression was detected in 1 of 15 cases with CD2^- and other 14 cases could complete remission after treatment. Conclusions：APL with CD2^＋ are often accompanied by high WBC counts and risk of serious bleeding,which can be used as an indicator to monitor the minimal residual disease of APL.

关 键 词：白血病 急性 早幼粒细胞性 免疫表型 CD2阳性 

分 类 号：R733.71[医药卫生—肿瘤]