局部晚期宫颈癌新辅助化疗25例近期疗效观察  

Short-term curative effect of neoadjuvant chemotherapy on locally adanced cervical cancer:a report of 25 cases

作　　者：靳丽杰[1] 方美丽[1] 叶国柳[1] 

机构地区：[1]蚌埠医学院第一附属医院妇产科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2012年第8期910-912,共3页Journal of Bengbu Medical College

摘　　要：目的:观察局部晚期宫颈癌患者术前行紫杉醇联合卡铂静脉化疗的临床疗效。方法:50例宫颈癌(ⅠB～ⅡA)患者中,25例术前给予PT方案(紫杉醇+卡铂)的新辅助静脉化疗,另25例为单纯手术对照组。患者均完成2个疗程化疗,化疗结束2周后观察局部肿瘤消退情况及化疗不良反应,按UICC疗效标准评价化疗疗效,并行宫颈癌根治术。结果:NACT组化疗后肿瘤直径较化疗前明显缩小(P<0.05),总有效率为76.00%,近期不良反应轻;NACT组手术时间和术中出血量及膀胱功能恢复时间均少于对照组(P<0.05～P<0.01),2组术后胃肠道功能恢复时间差异无统计学意义(P>0.05);NACT组术后高危病理因素发生率与对照组差异无统计学意义(P>0.05)。结论:局部晚期宫颈癌术前PT方案化疗可明显缩小原发灶体积,减少术后宫旁浸润、淋巴结转移,减少术后并发症和复发,值得临床上推广应用。Objective：To investigate the effect of preoperative neoadjuvant chemotherapy with PT on locally advanced cervical cell cancer. Methods： Fifty cases of locally advanced cervical cell cancer in stage Ⅰ B- Ⅱ A were retrospectively analyzed. Twenty-five cases were managed preoperatively by regiment of PT chemotherapy （ paclitaxel ＋ carboplatin） for 2 cycles and followed by the therapeutic value. The radical surgery was conducted after two weeks of the chemotherapy. The other 25 cases were only managed by radical surgery. Results ： Preoperative neoadjuvent chemotherapy with PT significantly decreased the primary tumor sizes （ P 〈 0.05 ）. The total effective rate was 76.00%. Chemotherapy adverse reaction in NACT group was light. Operation time and perioperative bleeding in NACT group was lower than those in the control group （ P 〈 0.05 to P 〈 0.01 ）. No significant difference existed in postoperative recovery time of bladder function and gastrointestinal function between two groups （ P 〉 0.05 ）. High-risk pathological factor rate in NACT group and control group was not statistically significant（ P 〉 0.05 ）. Conclusions：Preoperative chemotherapy with PT in locally adanced cervical cancer can reduce primary tumor sizes, decrease postoperative infiltration around uterine, reduce lymph node metastasis, and reduce the postoperative complications and recurrence. It is worthy of clinical application.

关 键 词：子宫颈肿瘤 新辅助化疗 紫杉醇 卡铂 

分 类 号：R737.33[医药卫生—肿瘤]