KAI1/CD82在喉鳞状细胞癌中的表达及其临床意义  

Expression and clinical significance of KAI1/CD82 in laryngeal squamous cell carcinoma

作　　者：张振寰[1] 吴礼高[2] 武世伍[2] 

机构地区：[1]安徽省全椒县人民医院病理科,239500 [2]蚌埠医学院第一附属医院病理科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2012年第8期930-932,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)中KAI1/CD82的表达及其与临床病理参数的关系。方法:应用免疫组织化学EliVisionTMplus法检测83例LSCC组织和20例正常喉组织中KAI1/CD82的表达情况。结果:KAI1/CD82在正常喉组织和LSCC组织中的阳性率分别为90.0%和41.0%,差异有统计学意义(P<0.01),且LSCC组织分化程度高、无淋巴结转移、临床Ⅰ～Ⅱ期者的KAI1/CD82阳性率均高于组织分化程度低、有淋巴结转移、临床Ⅲ～Ⅳ期者(P<0.05～P<0.01),而不同性别、年龄、肿瘤大小及肿瘤位置的LSCC者阳性率差异均无统计学意义(P>0.05)。结论:KAI1/CD82参与了LSCC组织的侵袭及转移,早期检测KAI1/CD82的表达可作为临床判断LSCC组织侵袭、转移的指标之一。Objective：To investigate the expression of KAI1/CD82 in laryngeal squamous cell carcinoma（ LSCC）, and its correlation with clinic pathological parameters. Methods：The expression of KAI1/CD82 of 83 specimens of LSCC tissue and 20 specimens of normal laryngeal tissue were detected by immunohistochemistry. Results：The positive expression rates of KAI1/CD82 in LSCC tissue and normal laryngeal tissue were 41.0% and 90.0% , respectively, which had significant difference （P 〈 0.01 ）. The high differentiation and no lymph node metastasis of LSCC tissues were observed. The positive expression rates of KAI1/CD82 of cases with grade Ⅰ - Ⅱ were significantly higher than that of cases with grade Ⅲ - Ⅳ and lymph node metastasis（P 〈0.05 to P 〈0.01 ） ,while its expression was not associated with age, gender, diameter and location of tumor（ P 〉 0.05 ）. Conclusions ：The expression of KAI1/CD82 is closely related to the invasion and metastasis of LSCC ,which can be an important indictor.

关 键 词：喉肿瘤 鳞状细胞癌 KAI1/CD82 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤]