胃腺癌组织中HDGF、VEGF的表达及意义  

Expression and significance of HDGF and VEGF in gastric adenocarcinoma

作　　者：马桂芳[1] 李惠芬[1] 杨李[1] 

机构地区：[1]盐城卫生职业技术学院,江苏盐城224006

出　　处：《重庆医学》2012年第22期2253-2255,F0003,共4页Chongqing medicine

摘　　要：目的探讨肝癌衍生生长因子(HDGF)与血管内皮生长因子(VEGF)在胃腺癌组织中的表达水平及意义。方法用免疫组织化学链霉菌抗生素蛋白-过氧化物酶连结法(S-P)法检测47例胃腺癌组织、15例胃黏膜不典型增生组织及10例因胃良性病变行部分切除的正常胃黏膜组织中HDGF和VEGF蛋白的表达水平。结果 HDGF在胃腺癌组织中的阳性表达率为65.9%,明显高于胃黏膜不典型增生组织(33.3%)及正常胃黏膜组织(20%),P<0.05;VEGF在胃腺癌组织中的阳性表达率为68.2%,明显高于胃黏膜不典型增生组织(20%)及正常胃黏膜组织(10%),P<0.05;HDGF和VEGF蛋白表达水平都与肿瘤的浸润深度、淋巴结转移、临床TNM分期之间有明显的相关性。结论 HDGF可能与VEGF共同参与了内皮细胞的增殖、分化及血管形成的调节,在胃腺癌的发生、发展及转移中起着重要的作用。Objective To investigate the expression and significance of hepatoma derived growth factor（HDGF） and vascular endothelial growth factor（VEGF） in gastric adenocarcinoma.Methods Immunohistochemical SP method was used to detect the expression levels of HDGF and VEGF in the gastric cancer of 47 cases,nontypical hyperplasia tissues 15 cases and normal gastric mucosa specimens obtained from 10 patients underwent partial gastrotomy for benign diseases.Results The positive rate of HDGF protein in gastric adenocarcinoma was 65.9%,which was significantly higher than 33.3% in nontypical hyperplasia tissues and 20% in normal gastric mucosa（P〈0.05）.The positive rate of VEGF protein in gastric adenocarcinoma was 68.2%,which was significantly higher than 20% in nontypical hyperplasia tissues and 10% in normal gastric mucosa（P〈0.05）.The expression of HDGF and VEGF was closely correlated to the invasive depth,lymph node metastasis and TNM stage.Conclusion HDGF and VEGF may be involved in regulation of endothelial cell proliferation,differentiation and angiogenesis,which may play an important role in the carcinogenesis and progression of gastric adenocarcinoma.

关 键 词：胃腺癌 HDGF VEGF 

分 类 号：R735.2[医药卫生—肿瘤]