CXCL12/CXCR4轴介导的信号通路与急性白血病  

CXCL12/CXCR4 Axis Mediated Signal Pathway and Acute Leukemia

作　　者：傅磊[1] 李振江[1] 杨桂玲[1] 

机构地区：[1]南昌大学第二附属医院血液科,江西南昌330006

出　　处：《医学与哲学（B）》2012年第7期40-41,52,共3页Medicine & Philosophy(B)

基　　金：国家自然科学基金;项目编号:30800490;江西省自然科学基金;项目编号:2007GQY1185

摘　　要：趋化因子受体CXCR4与其特异性配体CXCL12结合,形成CXCL12/CXCR4生物学轴,可以介导体内多个信号通路的转导,并受多种因子的调节,与白血病细胞的存活、生长、迁移、浸润、耐药、复发等密切相关。针对CXCL12/CXCR4轴的靶向治疗为白血病的治疗开辟了新途径。Chemokine receptor CXCR4 and its specific ligand CXCL12 combined with the formation of CXCL12/CXCR4 bio- logical axis. It can be mediated by multiple signaling pathways, and is subject to a variety of cytokines. The survival, growth,migration,invasion, drug resistance and relapse of the leukemia cell are closely related with CXCL12/CXCR4. The targeted therapy according to CXCL12/CXCR4 axis of for leukemia treatment has opened up a new way.

关 键 词：CXCL12/CXCR4轴 白血病 信号通路 调节因子 治疗 

分 类 号：R733.71[医药卫生—肿瘤]