扩张型心肌病的离子通道发病机制研究进展  

Current Status of Research in Dilated Cardiomyopathy Pathogenesis in Ion Channels

作　　者：万伟[1] 周显顺[1] 蔡红专[1] 

机构地区：[1]麻城市人民医院心内科,湖北麻城438300

出　　处：《心血管病学进展》2012年第4期551-553,共3页Advances in Cardiovascular Diseases

摘　　要：扩张型心肌病是一侧或双侧心腔扩大、心肌收缩功能障碍为主要特征的心肌疾病。其发病机制可能与病毒感染、免疫反应以及遗传因素有关。近年来研究发现心脏钠通道基因突变可导致扩张型心肌病。因此,现重点从心肌细胞离子通道的角度来论述扩张型心肌病的发病机制,探讨其治疗的新靶点。Dilated cardiomyopathy { DCM） is a myocardial disease in which the unilateral or bilateral chambers of the heart expand and myocardial contraction is weakened. The pathogenesis may be associated with viral infections, immune response and genetic factors. Re- cently, studies have found that the cardiac sodium channel gene mutations can cause DCM. This review discusses the pathogenesis of dilated cardiomyopathy from the perspective of myocardial cell ion channels in order to explore a new therapeutic target.

关 键 词：扩张型心肌病 SCN5A基因 钠通道 心肌细胞 

分 类 号：R542.2[医药卫生—心血管疾病]