RRM1和ERCC1在非小细胞肺癌中的表达及意义  

Expression and prognostic significance of ERCC1 and RRM1 in non-small cell lung cancer

作　　者：胡跃云[1] 张献波[1] 董英辉[1] 乞国艳[1] 张燕[1] 刘津来[1] 

机构地区：[1]石家庄市第一医院,石家庄050011

出　　处：《山东医药》2012年第21期1-3,共3页Shandong Medical Journal

基　　金：河北省科技支撑计划项目(09276121)

摘　　要：目的探讨DNA修复基因家族成员ERCCl、RRM1在非小细胞肺癌(NSCLC)中的表达及意义。方法应用免疫组织化学PV-9000法对30例NSCLC患者肿瘤组织中的ERCC1、RRM1蛋白表达进行检测。用χ2检验、相关分析、Kaplan-Meier生存曲线进行统计分析。结果 NSCLC患者肿瘤组织中,ERCC1和RRM1表达与患者性别、年龄、分期、病理类型、是否吸烟等参数无明显相关;ERCC1和RRM1的表达呈正相关(r=0.439,P=0.027);ERCC1阴性组的总生存期和无疾病进展生存期均明显长于ERCC1阳性组,RRM1阴性组的总生存期和无疾病进展生存期均明显长于RRM1阳性组(P<0.05或<0.01)。结论 ERCC1和RRM1在NSCLC肿瘤组织中的表达具有相关性,ERCC1和RRM1低表达提示NSCLC患者生存期长、生活质量高,RRM1和ERCC1高表达者对吉西他滨+顺铂化疗耐药,可作为判断其预后的指标,指导临床个体化用药。Objective To investigate the expressions of ERCC1 and RRM1 in patients with non-small cell lung cancer （NSCLC） as well as their clinical prognostic significance. Methods ERCC1 and RRM1 in 30 cases of IIIB/IV non-small cell cancer were detected by PV-9000 immunohistochemistry. The chi-square test, Fisher~ test, rank correlation, Kaplan- Meier survival curve were used for statistical analysis. Results There was no significant difference between the RRM1 or ERCC1 expression and sex, age, pathological type or TNM stage （ all P 〉 0.05 ）. There was a positive correlation between ERCC1 and RRM1 expressions （P = 0.015 ）. The ERCC1 negative group on overall survival and progression-free survival time were significantly longer than those in positive group, the RRM1 negative group on overall survival and progression-free survival time were significantly longer than those in positive group. Conclusions There was a correlation between ERCC1 and RRMI expression in NSCLC. The lower expression of ERCC1 and RRM1 were related with the longer survival time- and quality-dependent mode. The expressions of ERCC1 and RRM1 can be predicted with gemcitabine for advanced non-small cell lung cancer effects of chemotherapy. Chemotherapy can be used as the selection of individual chemotherapy at the time of reference.

关 键 词：癌 非小细胞肺 DNA修复酶类 预后 ERCC1 RRM1 

分 类 号：R734.2[医药卫生—肿瘤]