急性脑梗死患者颈动脉内中膜厚度与ox-LDL的相关性研究  

Correlation study of carotid intima-media thickness and ox-LDL in patients with acute cerebralinfarction

作　　者：韩立堂[1] 朱海燕[1] 滕继军[2] 

机构地区：[1]山东省潍坊市寒亭区人民医院,261100 [2]青岛大学医学院附属医院神经内科

出　　处：《中国实用医刊》2012年第16期62-63,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨急性大动脉粥样硬化性脑梗死（AACI）患者颈动脉内中膜厚度（IMT）以及与血清氧化型低密度脂蛋白胆固醇（ox-LDL）的关系。方法选择89例AACI患者与70例正常对照组进行颈动脉超声检查，检测颈动脉内中膜厚度，同时行血清ox-LDL检测。结果颈动脉内中膜厚度及ox-LDL与AACI具有显著相关性；急性大动脉粥样硬化性脑梗死患者血清ox-LDL浓度高于对照组（P〈0．05）；颈动脉内中膜增厚组和动脉斑块组高于内膜正常组（P〈0．05）；颈动脉斑块组高于颈动脉内中膜增厚组（P〈0．05）。结论ox-LDL在急性脑梗死（ACI）的发病过程中起重要作用，检测患者血清ox-LDL的浓度有助于了解这种状态和推测疾病的严重程度。Objective To investigate the relationship between carotid intima-media thickness （IMT） and oxidized low-density lipoprotein （ox-LDL） in patients with acute atherosclerotic cerebral in- farction （AACI）. Methods The carotid IMT were measured by ultrasound and the serum ox-LDL levels were detected in 89 patients with AACI and 70 healthy control subjects. Results There were significant correlation of carotid IMT and serum ox-LDL with AACI, the serum levels of ox-LDL in patients with AA- CI were higher than those in the healthy control subjects （ P 〈 0. 05 ） , the serum levels of ox-LDL in pa- tients with increased carotid intima-media thickness and atherosclerotic plaque were higher than those in normal carotid intima-media thickness subjects （P 〈 0. 05）, the serum levels of ox-LDL in patients with atherosclerotic plaque were higher than those in increased carotid intima-media thickness （P 〈 0.05 ）. Conclusions ox-LDL may play an important role in the development of acute cerebral infarction （ACI）. The concentration of the serum ox-LDL is helpful to estimate the degree of ACI.

关 键 词：急性脑梗死 颈动脉内中膜厚度 氧化型低密度脂蛋白胆固醇 

分 类 号：R74[医药卫生—神经病学与精神病学]