双环醇对实验性非酒精性脂肪肝大鼠的防治作用  

Preparation of Bicyclol in the prevention and treatment of the experimental rats with nonalcoholic fatty liver disease

作　　者：张文缓 张国顺[2] 王娜[2] 魏丽[2] 郭红[2] 马利转 王玉虎 卢丽霞 

机构地区：[1]武警河北总队医院唐山分院超声科,河北唐山063000 [2]河北联合大学附属医院消化内科,河北唐山063000

出　　处：《中国医药导报》2012年第22期20-21,共2页China Medical Herald

基　　金：河北省唐山市科技攻关指令项目(081302010)

摘　　要：目的探讨双环醇对非酒精性脂肪肝大鼠的防治作用。方法采用高脂饲料饲养制备非酒精性脂肪肝大鼠模型,同时给予不同剂量双环醇治疗,通过检测血清肝酶谱丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、转肽酶(GGT),血脂,肝组织匀浆三酰甘油含量和肝脏组织学变化,观察不同剂量双环醇对非酒精性脂肪肝大鼠的防治作用。结果模型组大鼠肝脏出现明显的脂肪变性,肝酶活性(AST、ALP、GGT),血脂和肝组织三酰甘油含量升高;双环醇各剂量组肝细胞脂肪变显著减轻,肝酶活性(AST、ALP、GGT)、血脂和肝组织三酰甘油含量较模型组显著下降。结论双环醇对非酒精性脂肪肝具有良好的防治作用。Objective To investgate the preventive and therapeutic effect of preparation of Bicyclol on the rats with nonalcoholic fatty liver disease （NAFLD）. Methods The fatty liver model was established by feeding with high caloric laboratory chaw, and treated with different dose of Bicyclol, the activities of alkaline phosphatase （ALT, AST, ALP, GGT） and gamma glutamyl transferase, blood lipid, liver triglycerin and pathological changes in all groups were assayed, and to observe the preventive and therapeutic effect of preparation of Bicyclol on the rats with NAFLD. Results The activities of alkaline phosphatase （AST, ALP, CCT） and gamma glutamyl transferase, blood lipid, liver triglycerin of model group increased significantly; liver histology showed mild to moderate steatosis. Those indexes of Bicyclol groups were significantly lower than those of model group. Conclusion Bicyclol is effective on the prevention and therapy of the rats with NAFLD.

关 键 词：双环醇 非酒精性脂肪肝 大鼠 

分 类 号：R575.5[医药卫生—消化系统]