晚期肺癌患者并发肺部感染的病原菌及药敏分析  

Pathogenic bacteria and their drug sensitivity in patients with advanced lung cancer accompanying lung infection

作　　者：于海容[1] 张丽娜[1] 薛庆亮[1] 薛新颖[1] 王娜[1] 杨冰[1] 汪建新[1] 

机构地区：[1]解放军总医院呼吸科,北京100853

出　　处：《军医进修学院学报》2012年第8期842-844,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的探讨晚期肺癌患者并发肺部感染的病原菌种类及药敏情况。方法统计我院2009年3月-2011年5月收治的56例Ⅳ期肺癌伴肺部感染的患者,对所有患者的痰菌培养及药敏试验结果进行回顾性分析。结果共分离菌株228株,其中G-菌113株(49.56%),以铜绿假单孢菌占首位(18.86%),其次为鲍曼氏不动杆菌、嗜麦芽窄食单胞菌、肺炎克雷伯杆菌及大肠埃希氏菌等;G+菌47株(20.61%),以凝固酶阴性葡萄球菌为主(10.09%),其次为屎肠球菌、金黄色葡萄球菌等。真菌菌株68株(29.82%),以白色念珠菌为主(14.04%)。G-菌主要对头孢他啶、氨基糖甙类、碳青酶烯类敏感,G+菌主要对万古霉素、替考拉宁、利奈唑胺敏感,真菌主要对氟康唑敏感。结论晚期肺癌合并肺部感染主要以G-菌为主,常伴有真菌感染,根据药敏结果合理应用抗生素是治疗的关键。Objective To study the pathogenic bacteria and their drug sensitivity in patients with advanced lung cancer accompanying lung infection.Methods Sputum culture and drug sensitivity test data about 56 patients with advanced lung cancer accompanying lung infection admitted to our hospital from March 2009 to May 2011 were retrospectively analyzed.Results Two hundred and twenty-eight strains were isolated from sputum.Of these strains,113（49.56%）were Gram-negative bacteria with Pseudomonas aeruginosa accounted for 18.86% followed by Bowman amobile bacteria,Klebsiella pneumoniae and E.coli,47（20.61%）were Gram-positive bacteria with coagulase negative staphylococcus accounted for 10.09% followed by Mycobacterium stercoris and Staphylococcus aureus,68（29.82%）were fungi with Candida albicans accounted for 14.04%.The Gram-negative bacteria were sensitive to ceftazidime,aminoglycoside and carbapenem.The Gram-positive bacteria were sensitive to vancomycin,teicoplanin and linezolid.Fungi were sensitive to fluconazole.Conclusion Gram-negative bacteria are the main pathogens in patients with advanced lung cancer accompanying lung infection.The key to its treatment is the rational use of antibiotics according to their drug sensitivity test

关 键 词：肺癌 肺部感染 痰培养 药敏试验 

分 类 号：R734.2[医药卫生—肿瘤]