局限性和系统性硬皮病皮损的组织病理特征及bcl-2蛋白表达  

Histopathologic characteristics and expression of bcl 2 protein in skin lesions of localized and systemic scleroderma patients

作　　者：谭庆梅[1] 翁孟武[1] 

机构地区：[1]上海医科大学华山医院皮肤科,200040

出　　处：《上海医学》2000年第3期135-137,共3页Shanghai Medical Journal

摘　　要：目的　观察局限性硬皮病 (LS)和系统性硬皮病 (SS)皮损的组织病理特征 ,检测这两类硬皮病皮损bcl 2蛋白的表达。方法　采用苏木素 伊红染色法和免疫组化方法。结果　LS皮损的炎症浸润细胞和真皮上网状层胶原束增粗均比SS皮损更常见 ,真皮乳头层胶原纤维硬化在LS皮损很常见 ,SS皮损却无此现象 ;两类硬皮病皮损的浸润淋巴细胞均表达bcl 2蛋白 ,且病程不超过 1年的硬皮病皮损浸润淋巴细胞bcl 2蛋白的表达为 ++或 +++的阳性率 ( 83 %)明显高于病程超过 1年的患者 ( 1 3 %,χ2 =1 9.4 6,P <0 .0 0 5 )。结论　两类硬皮病的发病机理可能不尽相同 ,但淋巴细胞bclThe histopathologic characteristies and expression of bcl 2 protein in skin lesions of patients with localized (LS)and systemic scleroderma (SS) were observed. We found that (1)The inflammatory infiltrative cells and thick collagenous bundles were more frequently seen in LS than in SS, sclerosis of papillary dermis was frequently seen in LS but absent in SS;(2) The expression of bcl 2 proteins in infiltrative lymphocytes of skin lesions in both types of infiltrative scleroderma and duration of its expression of less than one year was stronger than those more than one year.These suggest that there might be some difference in the pathogenesis of LS and SS, and the marked expression of bcl 2 protein in lymphocytes may be relevant to the pathogenesis of both diseases. (Shanghai Med J, 2000,23∶135 137)

关 键 词：局限性硬皮病 系统性硬皮病 BCL-2蛋白 病理 

分 类 号：R361.2[医药卫生—病理学]