Fn在膀胱癌组织中的分布及意义  

Fibronectin(Fn) Distribution and Significance in Bladder Cancer

作　　者：郭剑明[1] 张永康[1] 孙宝荣[2] 戎瑞明[1] 

机构地区：[1]上海医科大学中山医院泌尿外科,200032 [2]上海医科大学中山医院病理科,200032

出　　处：《中国临床医学杂志》2000年第1期34-35,共2页

基　　金：吴阶平泌尿外科医学基金!编号97007

摘　　要：目的：探讨纤维连接蛋白（Ｆｎ）在正常膀胱及膀胱癌组织中的分布情况。方法：应用免疫组化技术对５例正常膀胱组织，３３例膀胱癌组织中的Ｆｎ分布进行了观察。结果：发现正常膀胱组织中Ｆｎ分布于基膜及粘膜下组织，上皮层无Ｆｎ。而膀胱癌组织中基膜 Ｆｎ有不同程度的丧失，Ｆｎ表达阴性或弱阳性为 ６３．６％（２１／３３）。浸润性癌及分化差的膀胱癌组织中 Ｆｎ丧失明显， １２例浸润性膀胱癌中，１０例 Ｆｎ表达阴性或弱阳性为 ８３．３％（１０／１２）。 １３例有复发转移的患者，Ｆｎ表达阴性或弱阳性的为 １０例（７６．９％）。结论：作为细胞外基质主要成分的Ｆｎ在膀胱癌中均有不同程度的丧失，且Ｆｎ丧失越多，膀胱癌浸润程度越高，越容易复发转换。Objective: To investigate the distribution of Fn in normal and cancer tissue of bladder. Method: 5 cases of normal bladder tissue and 33 cases of bladder cancer tissue were evaluated by an immunohistochemistry eassay. Results: Fn was observed at the basement membrance and submucosa in the normal bladder tissue, not in the epithelial. But in bladder cancer, there was different degree of Fn loss in the basement membrane, the rate of negative or weakly positive of Fn expression was 63. 6 % (21/33). The deeper the tumor invasion or the poorer the tumor differentiation, the more the loss of Fn. Among 12 invasive bladder cancer, 10 expressed Fn negative or weakly positive (83. 3 % ). Among 13 recurrence or metastasis, 10 showed Fn loss (76. 9 % ). Conclusin: There was different loss of Fn in the bladder cancer, and the degree of basement Fn loss was closely related to the degee of tumor invasion or the incidence of recurrence.

关 键 词：膀胱肿瘤 纤维连接蛋白 FN 肿瘤侵润 肿瘤转移 

分 类 号：R737.140.2[医药卫生—肿瘤] R73－37[医药卫生—临床医学]