体检人群中大肠腺瘤性息肉与非酒精性脂肪肝的相关性研究  

Relationship between Colorectal Adenomatous Polyps and Non-alcoholic Fatty Liver Disease in A Physical Check-up Population

作　　者：陈长喜 季峰[2] 毛玉山[3] 杜娟 缪敏 徐益敏 张成 李静 

机构地区：[1]浙江省宁波市镇海区炼化医院消化内科,315207 [2]浙江大学医学院附属第一医院消化内科 [3]宁波大学附属医院内分泌科

出　　处：《中国全科医学》2012年第20期2277-2279,共3页Chinese General Practice

摘　　要：目的调查大肠腺瘤性息肉和非酒精性脂肪肝(NAFLD)在体检人群中的检出率,探讨两者的相关性。方法对2008年3月—2010年10月符合分析条件的2 715例全结肠镜体检者的一般资料、病理结果、上腹部B超、生化学指标进行回顾性分析,通过多因素非条件Logistic回归分析寻找大肠腺瘤性息肉的独立相关因素。结果大肠腺瘤性息肉组患者年龄、尿酸、低密度脂蛋白胆固醇、体质指数、腰围、收缩压、舒张压高于非腺瘤性息肉组,高密度脂蛋白胆固醇低于非腺瘤性息肉组,差异均有统计学意义(P<0.05);大肠腺瘤性息肉组NAFLD检出率(31.9%)高于非腺瘤性息肉组(20.4%),差异有统计学意义(P<0.05)。多因素非条件Logistic回归分析显示,NAFLD与大肠腺瘤性息肉相关〔OR=1.73,95%CI(1.28,2.35),P=0.012〕;性别、低密度脂蛋白胆固醇也与大肠腺瘤性息肉有一定的相关性(P<0.05)。结论 NAFLD为大肠腺瘤性息肉发病的独立相关危险因素,此类人群应作为大肠腺瘤性息肉的重点筛查对象。Objective To investigate the detection rate of colorectal adenomatous polyps and non-alcoholic fatty liver disease（NAFLD）in a physical check-up population and to investigate the relationship between NAFLD and colorectal adenomatous polyps.Methods The demographic data,pathological findings,abdominal ultrasound findings,and biochemical results were retrospectively analyzed in 2 715 qualified subjects who received physical examination with colonoscopy from March 2008 to October 2010.Logistic multiple regression analysis was used to identify the independent risk factors of adenomatous polyps.Results Colorectal adenomatous polyps patients had a significantly higher levels of uric acid and low-density lipoprotein and significantly higher body mass index（BMI）,waist circumference,systolic pressure,and diastolic pressure than the non-adenomatous polyps subjects（P〈0.05）.Colorectal adenomatous polyps patients（31.9%） had a higher detection rate of NAFLD than healthy controls（20.4%）（P〈0.05）.Multivariate unconditional Logistic regression analysis revealed that NAFLD had an significantly correlation with colorectal adenomatous polyps（OR=1.73,95%CI（1.28,2.35）,P=0.012）.In addition,colorectal adenomatous ployps was also correlated with gender and low-density lipoprotein cholesterol（P〈0.05）.Conclusion NAFLD is an independent risk factor of colorectal adenomatous polyps.

关 键 词：体格检查 大肠腺瘤性息肉 脂肪肝 非酒精性 

分 类 号：R574.6[医药卫生—消化系统] R575.39[医药卫生—内科学]