手性-3,5-二取代-1’,2',4'-三唑-[3',4'-b]-2,4-二氢间噻二嗪的合成及生物活性  

Synthesis and the Biological Activity of Chiral 3,5- Disubstituted S - Triazolo[3,4 - b] - 2,4 - Dihydrogen - 1,3,5 - Thiadiazines

作　　者：史好新[1] 王忠义[1] 史海健[1] 

机构地区：[1]安徽师范大学化学系,芜湖241000

出　　处：《有机化学》2000年第3期344-347,共4页Chinese Journal of Organic Chemistry

基　　金：安徽省自然科学基金;安徽省教委基金

摘　　要：以３－芳基－５－巯基－１，２，４－均三唑为原料，和甲醛及Ｓ－（－）－α－苯乙胺在酸催化作用下合成了６种新的化合物。研究了合成反应的条件。通过元素分析、ＩＲ、＾１ＨＮＭＲ、和ＭＳ确证了其结构，测定了比旋光度和生物活性。结果表明，一些化合物具有一定的抗菌活性。Six Novel compounds were synthesized by the reaction of 3 - aryl - 5 - mercapto - 1,2,4 - 5 - triazoles with formaldehyde and S-(-)-a- phenylethylamine in the presence of as acid catalyst. The reaction conditions were investigated. The structure of these compounds were established by elemental analysis, IR, 1H NMR, MS and specificro-tation. Some these compounds show that some compounds possess strong antibacterial activities.

关 键 词：1 3 5-噻二嗪 合成 抗菌活性 均三唑 

分 类 号：O626[理学—有机化学]