血清microRNAs在胃肠道疾病中的意义  

Significance of serum microRNAs in patients with gastrointestinal diseases

作　　者：熊青[1] 徐龙[1] 

机构地区：[1]南昌大学第一附属医院消化内科,江西省南昌市330006

出　　处：《世界华人消化杂志》2012年第22期2043-2049,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81060037~~

摘　　要：microRNAs(miRNAs)是一类长19-23个核苷酸的小分子单链RNAs,在转录后水平调节靶基因的表达,参与调控多种正常细胞过程以及肿瘤发生.已有证据证实,不少miRNAs参与胃肠道疾病的发生和发展,病变组织中异常表达的miRNAs,可作为胃肠道疾病特异性诊断的分子标志,但检测组织中的miRNAs用于早期诊断疾病有其自身的局限性.血清miRNAs也具有用于诊断胃肠道疾病的潜能,为胃肠道疾病的早期诊断提供一种新的非侵入性检测方法,并可能应用于疾病的预后评估、监测和治疗等领域.现就血清miRNAs的来源、特点、检测方法及在胃肠道疾病的意义作一综述.MicroRNAs（miRNAs） are a class of small single RNAs 19-23 nucleotides in length that regulate target gene expression at the post-transcriptional level and participate in normal biological processes and tumorigenesis.Some evidence proves that various miRNAs are involved in the pathogenesis of gastrointestinal diseases.MiRNAs that are expressed abnormally in lesions can be used as biomarkers for the specific diagnosis of gastrointestinal diseases.But testing miRNAs in the tissue for early diagnosis has its limitations.Serum miRNAs also can be used potentially for diagnosis of gastrointestinal diseases.They provide a new noninvasive detection method for early diagnosis,prognostic assessment,monitoring,and treatment of gastrointestinal diseases.This article reviews the source,features,detection methods for serum miRNAs,as well as the significance of serum miRNAs in patients with gastrointestinal diseases.

关 键 词：胃肠道 血清miRNAs 诊断 肿瘤 

分 类 号：R57[医药卫生—消化系统]