淀粉样变脑出血的临床特点及诊断方法  

Clinical manifestations and diagnosis of cerebral amyloid angiopathy

作　　者：孟庆虎[1] 赵珊珊[2] 曲春城[1] 魏胜程[1] 于锐[1] 赵旭[1] 王益华[1] 丁璇[1] 王志刚[1] 

机构地区：[1]山东大学第二医院神经外科,济南250033 [2]兖州市人民医院神经内科

出　　处：《中华神经外科杂志》2012年第8期823-825,共3页Chinese Journal of Neurosurgery

基　　金：山东省科技攻关课题（2007GG2000273）

摘　　要：目的 分析演粉样变脑出血的临床特点及诊断方法。方法 对55例自发性脑出血患者的临床表现及预后进行总结，对病理标理标本进行刚果红特殊染色和β淀粉样蛋白免疫组化染色，以明确病理诊断。结果 55例中6例首诊为可疑性淀粉样变脑出血，1例通过病理染色予以排除；2例术前诊断为可疑高血压性脑出血的患者经病理染色确诊为淀粉样变脑出血。结论 淀粉样变脑出血术前可以根据临床特点做出初步诊断； 是对于临床表现不典型者，诊断上还有一定的困难，病理分析仍然是诊断的金标准。目前对于此病的临床诊断方法需进一步研究改进。Objective To analyze the clinical manifestalinns and diagnosis methods of cerebral amyloid anginpatily （CAA）. Methods The clinical data of 55 patients with spontaneous intracerebral hemorrhage were analyzed. The pathological specimen were stained by Cnngn red and accepted immunohislochemistry staining fnr beta -amyloid protein. Then the pathological diagnoses were established. Results 6 patients were first diagnosed as CAA depend on the elinical manifestation, but one patient was later excluded by pathological staining. Two patients were firsl diagnosed as hypertensive intraeerebral hemorrhage, and then were identified as CAA by pathological staining. Conclusions CAA could be the first diagnosis depended on its clinical features. But as for the atypical patient, the diagnosis should be determined by palholngical diagnosis, which re,nained to be the gold standard for CAA. The diagnosis methods of CAA need further research and improvement.

关 键 词：淀粉样变脑血管病 临床特点 诊断 

分 类 号：R743.3[医药卫生—神经病学与精神病学]