正丁醇萃取技术制备高纯度栀子苷的工艺研究  

Study of preparation process for high purity of Geniposide by extraction technology with butanol

作　　者：丁越[1] 张彤[1] 陶建生[1] 郭春荣[1] 金旻逸[1] 

机构地区：[1]上海中医药大学,上海201203

出　　处：《中国新药杂志》2012年第14期1596-1599,共4页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项(2009ZX09103-449);上海市人才发展基金(2011015);上海市教委计划内资助项目(2010JW21)

摘　　要：目的:优化正丁醇萃取技术制备高纯度栀子苷的工艺。方法:以精制品中栀子苷的含量和栀子苷的转移率为指标,优选正丁醇萃取技术纯化栀子苷的最佳工艺。结果:正丁醇萃取工艺为:取栀子苷粗提物适量,加20倍量的水使之溶解,分别加入正丁醇萃取2次,每次正丁醇用量为栀子苷粗提物质量的20倍,收集正丁醇萃取液,回收正丁醇,干燥,收集白色粉末状样品。结论:此工艺简便易行,效率高,可用于制备纯度高于90%的栀子苷。Objective：To optimize the process for preparation of high purity geniposide. Methods：Using the content and transfer ratio of geniposide as the parameters,the process for purification of geniposide by extraction technology with butanol was optimized. Results：The optimal process for purification of geniposide was as follows： dissolve the crude geniposide extract with water of 20 times volume, carry out liquid-liquid extraction with the same volume of butanol for 2 times, collect the butanol part, recycle the butanol and dry in vacuum to get the white powder which was the purified geniposide. Conclusion：This process is simple and affordable,and can be used to prepare geniposide with purity of higher than 90%.

关 键 词：栀子苷 正丁醇 液-液萃取 制备 

分 类 号：R284[医药卫生—中药学]