自身对照法测定复方黄连素片溶出度  

Determination of dissolution of the compound huangliansu tablets by self-control method

作　　者：谢元超[1] 巩丽萍[1] 徐晓洁[1] 聂延君[1] 

机构地区：[1]山东省食品药品检验所,济南250101

出　　处：《药物分析杂志》2012年第8期1486-1489,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立自身对照法测定复方黄连素片溶出度。方法:采用自身对照法(UV)测定复方黄连素片的溶出度。采用篮法,溶出介质为纯化水(900 mL),转速100 r.min-1,取样时间90 min。结果:复方黄连素片溶出度测定自身对照法在1.2～9.0μg.mL-1浓度范围内呈线性(r=0.9995,n=5),回收率98.9%,RSD=0.03%。结论:本法简便、准确、可行,可作为复方黄连素片的质量标准中控制项目之一。Objective：To establish a self-control method for determination the dissolution of the compound huangliansu tablets.Methods：The UV spectrophotometry method was applied to determine the dissolution of the compound huangliansu tablets.Basket apparatus was used with water as the dissolution medium at a speed of 100 r·min-1 and dissolution time limit was 90 min.Results：The linear range of the compound huangliansu tablets was 1.2-9.0 μg·mL-1 and the correlation coefficient was 0.9995.The average recovery was 98.90%,and the RSD was 0.03%.Conclusion：The method is convenient,accurate and practicable.It can be applied to determine the dissolution of the tablets.

关 键 词：复方黄连素片 盐酸小檗碱溶出度 自身对照法 紫外分光光度法 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学]