中晚期大肠癌患者化疗前后血清IGF-Ⅰ和TGF-α检测及临床意义  

Clinical Significance of the Change of Serum IGF-Ⅰand TGF-α Level after Chemotherapy in Patients with Advanced Colorectal Cancer

作　　者：侯亚莉[1] 华克胜[2] 

机构地区：[1]菏泽医学专科学校,山东菏泽274000 [2]菏泽市立医院

出　　处：《中外医学研究》2012年第22期50-51,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察中晚期大肠癌患者化疗前后血清IGF-Ⅰ及TGF-α的水平变化,并探讨其对复发的临床意义。方法:通过放射免疫分析法测定40例中晚期大肠癌患者化疗前、化疗后1个月及化疗后6个月的血清IGF-Ⅰ及TGF-α水平,并与40例正常健康人作比较。结果:中晚期大肠癌患者化疗前血清IGF-Ⅰ及TGF-α水平明显高于正常人(P<0.01);化疗后1个月时IGF-Ⅰ及TGF-α水平明显降低(P<0.01);化疗后6个月时,复发患者的IGF-Ⅰ及TGF-α水平明显高于未复发者(P<0.01)。结论:血清IGF-Ⅰ及TGF-α水平检测有助于判断化疗疗效、预测复发。Objective ：To observe the changes of serum IGF- I （Insulin-like growth factor- I ）and TGF-α（Transforming growth factor-or）in patients with advanced colorectal cancer before and after chemotherapy, so as to explore the clinical significance to recurrence.Methods ：The serum IGF- I and TGF- αin 40 patients with advanced colorectal cancer were detected before and after chemotherapy for one month and six months, as well as in 40 normal controls. Results ：Compared with those of before chemotherapy, the level of serum IGF- I and TGF-αdecreased dramatically in patients after chemotherapy for one month（P〈0.01）.But the level of serum IGF- I and TGF-αafter chemotherapy for six months were significantly higher in patients with recurrence compared with those without recurrence（P〈0.01）.Conclusion ：Detection of serum IGF- I and TGF-α was helpful to judge the chemotherapy effect and to forecast the

关 键 词：胰岛素生长因子-Ⅰ 转化生长因子Α 中晚期大肠癌 化疗 

分 类 号：R735.34[医药卫生—肿瘤]