脑白质损伤患者血液中碱性髓鞘蛋白及不对称二甲基精氨基酸的表达水平  

The clinical value for the detection of myelin basic protein and asymmetric dimethylarginine in patients with white matter lesions

作　　者：蒋超[1] 王建平[1] 

机构地区：[1]郑州大学第五附属医院神经内科,河南郑州450052

出　　处：《中国老年学杂志》2012年第16期3383-3384,共2页Chinese Journal of Gerontology

基　　金：河南省卫生厅重大科技攻关项目(No.WKJ 2011-2-019)

摘　　要：目的探讨脑白质损伤患者血液中碱性髓鞘蛋白及不对称性二甲基精氨酸的表达水平及可能的危险因素及诊断标志物。方法根据头颅MRI检查结果随机选取脑白质损伤患者36例及非脑白质损伤患者40例,通过酶联免疫吸附法及高效液相色谱法检测两组研究对象血液中碱性髓鞘蛋白及不对称性二甲基精氨酸的水平,相关分析评价二者之间的关系。结果脑白质损伤患者及非脑白质损伤患者血清中碱性髓鞘蛋白的水平分别为(3.52±1.09)μg/L与(1.79±0.70)μg/L,二者比较差异有统计学意义(P<0.05);脑白质损伤患者及非脑白质损伤患者血浆中不对称性二甲基精氨酸的水平分别为(1.57±0.51)μg/ml与(0.72±0.25)μg/ml,二者比较差异有统计学意义(P<0.05);相关分析结果表明血液中碱性髓鞘蛋白及不对称性二甲基精氨酸的表达水平呈正相关,相关系数为0.814(P<0.05)。结论脑白质损伤患者血液中碱性髓鞘蛋白及不对称性二甲基精氨酸的表达水平明显升高,不对称性二甲基精氨酸可能参与了脑白质损伤的过程,碱性髓鞘蛋白的检测可能有利于疾病的早期诊断。Objective To find the possible risk factor and diagnostic marker for patients with white matter lesions by detecting the expression level of myelin basic protein（MBP） and asymmetric dimethylarginine（ADMA） in the peripheral blood of theses patients.Methods 36 patients with white matter lesions and 40 patients without white matter lesions were randomly selected according their MRI results.ELISA technique and high-performance liquid chromatography method were used to detect the expression levels of MBP and ADMA in the peripheral blood of all patients.Correlation analysis was used to evaluate the relationship between MBP and ADMA.Results The results of MBP in two groups were（3.52±1.09）,（1.79±0.70） μg/L,respectively;ADMA evaluation of the two groups were（1.57±0.51）,（0.72±0.25） μg/ml,respectively.There was significant difference between this two groups（P〈0.05）.The correlation coefficient of MBP and ADMA was 0.814（P〈0.05）.Conclusions The expression levels of MBP and ADMA in patients with white matter lesions are significantly higher than those of patients without white matter lesions.ADMA may play important roles in the process of white matter lesions.It is clinically significant for the early diagnosis of white matter lesions by detecting MBP.

关 键 词：脑白质损伤 碱性髓鞘蛋白 不对称二甲基精氨基酸 相关分析 

分 类 号：R74[医药卫生—神经病学与精神病学]