^(99m)Tc-HL91单光子计算机断层扫描对脑梗死灶周围乏氧组织的检测  

Detection of hypoxic brain tissue around the cerebral infarction by ^(99m)Tc-HL91 single photon emission computerized tomography

作　　者：刘耿熙 杨友松[2] 

机构地区：[1]新沂市人民医院神经内科,221400 [2]四川省人民医院神经内科

出　　处：《临床神经病学杂志》2012年第4期260-262,共3页Journal of Clinical Neurology

摘　　要：目的探讨99mTc-HL91单光子计算机断层扫描(SPECT)对脑梗死灶周围乏氧组织的检测。方法应用99mTc-HL91 SPECT对29例脑梗死患者和5名健康对照者进行脑显像检测,并对脑梗死患者进行血压、血糖和血浆纤维蛋白原(Fib)水平检查。结果 SPECT示脑梗死组脑组织乏氧显像阳性18例(62.1%),正常对照组均阴性。Spearman秩相关分析显示,梗死体积≤30 cm3的患者乏氧显像阳性范围与SPECT检测时间呈负相关(rs=-0.624,P<0.05),与脑梗死体积呈正相关(rs=0.715,P<0.001)。结论99mTc-HL91SPECT检测可显示脑梗死灶周围乏氧组织。梗死灶体积≤30 ml的脑梗死患者SPECT检测时间越早,则乏氧显像的阳性率越高。Objective To investigate the detection of hypoxic brain tissue around the cerebral infarction （CI） by ^99mTc-HL91 single photon emission computerized tomography （SPECT） . Methods Brain imanging detection were applied in 29 CI patients and 5 healthy controls by ^99mTc-HLgl SPECT. The blood pressure, the levels of blood sugar and plasma fibrinogen （Fib） were checked in ACI patients. Results SPECT showed that 18 cases （62.1% ） in ACI group were hypoxia imaging positive, while there were all negative in normal control group. Hypoxic imaging positive range in ACI patients with infarct lesion volume ≤30 cm3 was negative correlated with the time of SPECT check （ rs = - 0. 624, P 〈 0. 05 ） ; and positive correlated with the infarction lesion volume （ rs = 0. 715, P 〈 0. 001 ）. Conclusions ^99mTc-HLgl SPECT can show the hypoxic brain tissue around the focus of cerebral infarction. When ACI patients with infarct lesion volume ≤30 cm^3 , the earlier checking with SPECT, the higher positive rates of hypoxic imaging.

关 键 词：脑梗死 乏氧显像 单光子计算机断层扫描 99mTc-HL91 

分 类 号：R743.3[医药卫生—神经病学与精神病学]