对高危型人乳头瘤病毒与子宫颈病变相关因素的探讨  

作　　者：周静[1] 朱艳[1] 毛维霞[1] 

机构地区：[1]南京中医药大学附属昆山中医医院,江苏南京215300

出　　处：《求医问药（下半月刊）》2012年第5期301-302,共2页Seek Medical and Ask The Medicine

摘　　要：目的:研究女性生殖道高危型人乳头瘤病毒(HR-HPV)检查方法在宫颈病变筛查中的应用价值。方法:收集1001名20～67岁、已婚或有性生活史的体检女性患者的宫颈外口及宫颈管分泌物,采用第二代杂交捕获试验(HC2)进行HPVDNA检测,所有患者均行阴道镜活组织检查。通过随诊对照其细胞学与组织学结果,探讨该技术在宫颈病变筛查中的应用价值。结果:在1001名检查对象中,高危型HPV感染者为216例。非高危型HPV感染者经阴道镜活组织检查,正常者784例(99.87%),异常者为1例(0.13%)。高危型HPV感染者经阴道镜活组织检查,正常者112例(51.85%),异常者为104例(48.15%)。结论:高危型HPVDNA检测是子宫颈疾病筛查的有效手段。Objective：To find out the application value of the method of the viral load of High-risk human papillomaviru（sHR-HPV） that established infection in the reproductive tracts of women testing in cervical lesions.Methods：The secretions of cervical os and canal of 1 001 women,aged from 20 to 67,who participated in the cross-sectional survey,and who were married or were single but already had sexual life,were collected and tested by HPV DNA testing,using the HC Ⅱ test.ALL patients who were positive for high-risk HPV or not had colposcopic biopsy,and in the follow-up,cytological and histological confirmation of their disease,in order that the application value of the method of HPV DNA testing could be identified.Results：Of the 1001 tested specimens,216 were found to be infected with high-risk HPV.Among the other 785 patients,who were not found to be infected with high-risk HPV,784（99.87%）were proved normal and 1例（0.13%）。abnormal by colposcopic biopsy.Among the patients who were found to be infected with high-risk HPV,112例（51.85%）were proved normal and 104例（48.15%）abnormal by colposcopic biopsy.Conclusion：The method of DNA test of high-risk types of HPV was proved to be effective in screening cervical lesions..

关 键 词：高危型人乳头瘤病毒(HR-HPV) 检测 子宫颈 病变 

分 类 号：R737.33[医药卫生—肿瘤]