Use of DNAzymes for cancer research and therapy  

作　　者：XU ZhiJie YANG LiFang SUN LunQuan CAO Ya 

机构地区：[1]Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health,Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education,Cancer Research Institute,Xiangya School of Medicine,Central South University,Changsha 410008,China [2]Center for Molecular Medicine,Xiangya Hospital,Central South University,Changsha 410008,China

出　　处：《Chinese Science Bulletin》2012年第26期3404-3408,共5页

基　　金：supported by the National Natural Science Foundation of China (30873010 and 81072220);the National High Technology Research and Development Program of China (2009AA02Z403)

摘　　要：DNAzymes(Dzs) are single-stranded DNA catalysts that specifically cleave the mRNA of targeted genes.Compared with other gene-silencing technologies,such as ribozymes,antisense oligonucleotide and small interference RNA(siRNA),DNAzymes have several advantages,including small molecular weight,diversity,low cost and relative stability in serum.With the evolution of molecular technology,the first DNAzyme was generated in vitro in 1994.From then on,DNAzymes have been studied in order to understand their structures,chemistry and biological applications.Particularly,DNAzymes have been widely applied as a new interference strategy in the treatment of many conditions,including cancer,viral diseases,and cardiovascular diseases.This review mainly summarizes the use of DNAzymes in the areas of cancer research and therapy.DNAzymes （Dzs） are single-stranded DNA catalysts that specifically cleave the mRNA of targeted genes. Compared with other gene-silencing technologies, such as ribozymes, antisense oligonucleotide and small interference RNA （siRNA）, DNAzymes have several advantages, including small molecular weight, diversity, low cost and relative stability in serum. With the evolution of molecular technology, the first DNAzyme was generated in vitro in 1994. From then on, DNAzymes have been studied in order to understand their structures, chemistry and biological applications. Particularly, DNAzymes have been widely applied as a new interference strategy in the treatment of many conditions, including cancer, viral diseases, and cardiovascular diseases. This re- view mainly summarizes the use of DNAzymes in the areas of cancer research and therapy.

关 键 词：脱氧核酶 治疗 癌症 小干扰RNA 分子生物技术 心血管疾病 反义寡核苷酸 病毒性传染病 

分 类 号：R730.5[医药卫生—肿瘤]