原发性高血压患者血清肿瘤坏死因子-α和-β水平测定及临床意义  

Serum tumor necrosis factor-α and -β levels and clinical significance in patients with essential hypertension

作　　者：郭利伟[1] 康丽霞[2] 黄艳梅[1] 梁爱华[2] 赵林静[1] 吴强[3] 

机构地区：[1]新乡医学院基础医学院,河南新乡453003 [2]新乡医学院第三附属医院检验科 [3]新乡市中心医院神经内科

出　　处：《临床心血管病杂志》2012年第8期581-583,共3页Journal of Clinical Cardiology

基　　金：河南省教育厅自然科学基金项目(No:2008A310010)

摘　　要：目的:探讨原发性高血压(EH)患者血清肿瘤坏死因子(TNF)水平变化与EH发生的关系。方法:ELISA法检测260例河南汉族EH患者和394名对照者的血清TNF-α及TNF-β水平。结果:与对照者比较,EH患者血清TNF-α及TNF-β水平均显著增高[(7.648±2.115)pg/ml︰(5.417±1.903)pg/ml,(6.036±1.227)pg/ml︰(4.925±1.737)pg/ml,均P<0.01]。EH患者血清TNF水平随收缩压和舒张压的升高而升高,呈正相关(均P<0.01)。结论:EH患者的血清TNF水平增高可能与EH的发生相关。Objective：To investigate the serum tumor necrosis factor（TNF） levels and clinical significance in patients with essential hypertension（EH） from Han population in Henan province.Method：The levels of TNF-α and TNF-β in serum were detected by ELISA in 260 EH patients and 394 controls of Henan Han population.Result：EH patients had significantly higher concentrations of serum TNF-α and TNF-β than controls [（7.648±2.115）pg/ml vs（5.417±1.903）pg/ml,（6.036±1.227）pg/ml vs（4.925±1.737）pg/ml,P〈0.01].The levels of TNF increased with the increasing of systolic blood pressure and diastolic blood pressure in EH patients.Conclusion：The increase of serum TNF-α and TNF-β in EH patients may be correlated with the progress of EH in Henan Han population.

关 键 词：高血压 原发性 肿瘤坏死因子 血清 汉族群体 河南 

分 类 号：R544.1[医药卫生—心血管疾病]