^(18)F-FDG PET/CT显像在^(131)I全身扫描及血清Tg均阴性的已清除残留甲状腺组织的分化型甲状腺癌患者中的应用价值  

Application of ^(18)F-FDG PET/CT in patients with negative findings in serum Tg measurement and ^(131)I-whole body scan after ablation of remaining thyroid tissues for differentiated thyroid carcinoma

作　　者：程维维[1] 王辉[1] 冯方[1] 傅宏亮[1] 李佳宁[1] 

机构地区：[1]上海交通大学医学院附属新华医院核医学科,上海200092

出　　处：《上海交通大学学报（医学版）》2012年第8期1068-1071,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市重点学科建设项目(S30203)~~

摘　　要：目的探讨18F-FDG PET/CT显像在血清Tg和131I-全身扫描均为阴性的行甲状腺癌切除和清除残留甲状腺组织治疗后的患者中检测肿瘤复发和转移的应用价值。方法 41例接受了甲状腺全切和大剂量131I清除残留甲状腺组织治疗的DTC患者,在随访中进行了血清Tg测定、131I-WBS、颈部B超、胸部CT及18F-FDG PET/CT全身显像。结果 41例患者血清Tg和131I-WBS均为阴性,颈部B超或胸部CT均显示存在异常病灶;其中23例患者18F-FDG PET/CT显像阳性,18例患者18F-FDG PET/CT显像阴性。18F-FDG PET/CT显像阳性患者中,有3例经病理检查证实为甲状腺癌转移;18F-FDG PET/CT显像阳性病灶与阴性病灶的长短径差异无统计学意义。结论接受甲状腺全切和大剂量131I清除残留甲状腺组织治疗后的DTC患者术后随访血清Tg及131I-WBS均为阴性时,18F-FDG PET/CT显像可显示可疑的阳性病灶,有助于发现复发和转移病灶。Objective To investigate the application of ^18F-FDG PET/CT in detection of tumor recurrence and metastasis among patients with negative findings in serum thyroglobulin （Tg） measurement and ^131 I-whole body scan （^131 I-WBS） after total thyroideetomy and ^131 I ablation of the remaining thyroid tissues for differentiated thyroid carcinoma （DTC） . Methods Forty-one patients with DTC underwent total thyroidectomy and ^131I ablation of the remaining thyroid tissues, and were followed up with serum Tg measurement, ^131I-WBS, neck ultrasound, chest CT and whole body ISF-FDG PET/CT. Results All these 41 patients had negative findings in serum Tg measurement and ,^131I-WBS, while abnormal lesions were detected by neck ultrasound or chest CT. Twenty-three patients had positive findings in ^18F-FDG PET/CT, 3 of whom were confirmed as thyroid carcinoma metastases by pathological examinations. There was no significant difference between the size of ^18F-FDG PET/CT positive lesions and that of ^18F-FDG PET/CT negative lesions. Conclusion ISF-FDG PET/CT may demonstrate suspicions positive lesions in patients with negative findings in serum Tg measurement and ^131I-WBS after total thyroidectomy and ^131I ablation of the remaining thyroid tissues for DTC, which may help in the detection of tumor recurrence and metastasis.

关 键 词：分化型甲状腺癌 131I全身扫描 血清甲状腺球蛋白 18F-FDG 

分 类 号：R736.1[医药卫生—肿瘤]