运脾方对小鼠肠推进作用的研究  

Study on intestinal propulsion effect of Yun-pi Prescription in mice

作　　者：严佳菁 孙远岭 周纬[1] 杨珍[1] 

机构地区：[1]上海交通大学医学院附属上海儿童医学中心,上海200127

出　　处：《现代中西医结合杂志》2012年第24期2648-2649,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海儿童医学中心-雅培/世界健康基金会临床营养发展中心(AFINS)资助项目(SCMC-YP-HOPE-KY-0814)

摘　　要：目的观察运脾方不同剂量对小鼠肠推进的作用,探讨运脾方在治疗小儿厌食症中发挥临床药效的作用机制。方法选取昆明种小鼠,分为正常组、阳性对照组和运脾方大剂量组、运脾方中剂量组、运脾方小剂量组,连续给药7 d后,给予炭末混悬液,测定小肠炭末推进率。结果运脾方大、中、小剂量组小鼠的小肠炭末推进率与正常组比较均明显降低。结论运脾方能够有效地减慢正常小鼠的肠推进,不仅有利于营养物质的吸收,而且为其药效发挥提供了充足的时间。Objective It is to observe the intestinal propulsion effects of Yun-pi Prescription in different dose in mice and to explore the mechanism of Yun-pi Prescription in treatment of children anorexia. Methods Sixty KM mice were randomly di- vided into groups as normal group, positive control group, and Yun-pi Prescription treatment groups including high-, middle- and low-dose. After 7 days treatment with homologous drug, the charcoal-powder propulsion rate of small intestine in mice was measured. Results The charcoal-powder propulsion rate of small intestine were all significantly reduced in the high-, middle- and low-dose groups of Yun-pi Prescription. Conclusion Yun-pi Prescription can effectively slow down the rate of intestinal propulsion in mice. It not only helps the absorption of nutrients, but also provides sufficient time to play its efficacy.

关 键 词：运脾方 厌食症 肠推进 动物实验 

分 类 号：R-332[医药卫生]