雷贝拉唑“三联”方案治疗消化性溃疡的抗菌及抗复发疗效观察  

Observations of the Anti-recrudescence and Antiseptic Curative Effect of Rabeprazole's Trigeminy Treating Project in Petic Ulcer

作　　者：杨拥政 

机构地区：[1]乐至县人民医院,四川乐至641500

出　　处：《西部医学》2012年第8期1607-1608,1610,共3页Medical Journal of West China

摘　　要：目的研究雷贝拉唑"三联"方案对消化性溃疡的抗菌(幽门螺杆菌Helicobacter pylori,Hp)及抗复发治疗疗效。方法 405例消化性溃疡病例随机分为3组,第1组135例,雷贝拉唑片+克拉霉素+阿莫西林,服药治疗1周后,继续单独使用雷贝拉唑,球部溃疡连续用药1周,胃溃疡和复合性溃疡予连续应用3周;第2组136例,雷贝拉唑片+克拉霉素+阿莫西林,治疗1周后,继续单独使用法莫替丁片,球部溃疡连续用药1周,胃溃疡和复合性溃疡连续用药3周;第3组134例,奥美拉唑胶囊+克拉霉素+阿莫西林,治疗1周后,继续单独使用法莫替丁片,球部溃疡连续用药1周,胃溃疡和复合性溃疡连续用药3周。然后分别随访复查半年后及一年内溃疡复发情况。结果 1、2、3组溃疡愈合率分别为96.3%、96.5%和87.3%,1、2与3组比较差异均有显著性(P<0.05);1、2、3组的HP清除率分别为94.3%、94.5%和81.6%,1、2与3组比较,Hp清除率差异有显著性(P<0.05);1组与2组比较,复发率差异有显著性(P<0.05),1组与3组比较,复发率差异亦有显著性(P<0.001),2组与3组比较,复发率差异有显著性(P<0.05)。结论雷贝拉唑片、克拉霉素及阿莫西林三联疗法治疗溃疡能迅速缓解消化性溃疡患者的症状,有效根除HP,短程治疗即具有较高的溃疡愈合率,延长服药2～4周,对预防溃疡的复发有重要意义,并可降低复发率。Objetive Study on the anti-recrudescence and antiseptic curative effect of Rabeprazole’s Trigeminy Treating Project in petic ulcer.Methods 405 patients are divided into three groups at random.Group One： 135 patients in all.After having taken the medicine which is composed of Rabeprazole Tablets,Clarithromycin Tablets and amoxicillin a week,they continue taking only Rabeprazole Tablets.As for the patients of bulb duodenal ulcer,they continue taking this a month;As to the patients of stomach ulcer and complexed ulcer,3 weeks;Group Two： 136 patients in all.After having taken the medicine which is composed of Rabeprazole Tablets,Clarithromycin Tablets and amoxicillin a week,they continue taking only famotidine Tablets.As for the patients of bulb duodenal ulcer,they continue taking this a month;As to the patients of stomach ulcer and complexed ulcer,3 weeks;Group Three： 134 patients in all.After having taken the medicine which is composed of Omeprazole Enteric Capsules,Clarithromycin Tablets and Amoxicillin a week,they continue taking only famotidine Tablets.As for the patients of bulb duodenal ulcer,they continue taking this a month;As to the patients of stomach ulcer and complexed ulcer,3 weeks.And then reexamine them half a year and a year later respectively at random.Results The ulcer healing rates of the three groups were 96.3%,96.5% and 87.3%.There were significant difference（P〈0.05） in the three groups.The elimination rate of Helicobacter Pylori were 94.3%,94.5% and 81.6%,and there were significant difference（P〈0.05） in the three groups.As for the recrudescence rate,there were significant difference（P〈0.05） between Group One and Group Two.And there were significant difference（P〈0.001） between Group One and Group Three.There were significant difference（P〈0.05） between Group Two and Group Three.Conclusion Rabeprazole Tablets,Clarithromycin Tablets and Amoxicillin can release the syptom of the patients who suffere from petic ulcer and get rid of Helicobacter Ploric effectively

关 键 词：雷贝拉唑 幽门螺杆菌 消化性溃疡 抗菌及抗复发治疗 

分 类 号：R573.1[医药卫生—消化系统]