北五味子提取物缓解体力疲劳作用的实验研究  

The Anti-Fatigue Effect of Schisandra Chinensis Bai11 Extract

作　　者：鲍春丹[1] 孙艳[1] 王凤前[1] 刘影[1] 单毓娟[1] 孙阔[1] 

机构地区：[1]哈尔滨医科大学食品药品安全评价中心,黑龙江哈尔滨150081

出　　处：《中医药信息》2012年第4期145-147,共3页Information on Traditional Chinese Medicine

基　　金：黑龙江省教育厅课题(11551243)

摘　　要：目的:探讨北五味子提取物对小鼠体力疲劳的缓解作用。方法:160只清洁级雄性ICR小鼠,随机分为4组,分别灌胃给予蒸馏水(对照组)、不同剂量北五味子提取物(10mL/kg、3.3 mL/kg、1.67mL/kg),每日1次,连续30天,进行负重游泳实验,测定血乳酸、血清尿素及肝糖原含量。结果:与对照组比较,北五味子提取物各剂量组均能显著延长小鼠负重游泳时间,增加肝糖原含量,降低运动后血清尿素水平,高剂量组对小鼠运动后血乳酸升高有明显的抑制作用。结论:北五味子提取物具有缓解小鼠体力疲劳的作用。Objective： To evaluate the anti- fatigue effect of Schisandra chinensis bail l extract （SCE） in mice. Methods ：160 clean male ICR mice were randomly divided into four groups. The mice in the control group were garaged with distilled water, while the others were respectively gavaged with SCE at 1.67mL/kg, 3.3mlMkg, 10mL/kg for consecutive 30 days. Then the experiments such as loading swimming, serum lactate acid, serum urea and liver glycogen were performed. Resuhs：SCE could significantly prolong the loading swimming time, reduce serum urea level and increase the content of liver glycogen. High concentration of SCE （10mL/kg） obviously reduced the lactate acid level. Conclusion：SCE possesses the function of anti -fatigue in mice.

关 键 词：北五味子提取物 负重游泳时间 乳酸 尿素 肝糖原 抗疲劳 

分 类 号：R285.5[医药卫生—中药学]