VEGF、MMP-7在乳腺导管原位癌、浸润性导管癌中的表达及相互关系  

RELATIONSHIP OF VEGF AND MMP-7 PROTEINS EXPRESSED IN BREAST DUCTAL CARCINOMA IN SITU AND INFILTRATING DUCTAL CARCINOMA

作　　者：张伟[1] 张飞燕[1] 李芳[1] 李璐[2] 安慧琴[3] 

机构地区：[1]河北省保定市第二医院病理科,河北保定071051 [2]河北大学附属医院麻醉科,河北保定071000 [3]河北省人民医院耳鼻喉科,河北石家庄050051

出　　处：《河北医科大学学报》2012年第8期914-918,F0003,共6页Journal of Hebei Medical University

摘　　要：目的探讨转移相关蛋白血管内皮生长因子(vaseular endothelial growth factor,VEGF)、基质金属蛋白酶-7(matrix metallo proteinases-7,MMP-7)在乳腺导管原位癌和浸润性导管癌中的表达及相互关系。方法采用免疫组织化学SP法检测导管原位癌25例、乳腺浸润性导管癌68例和正常乳腺组织17例中VEGF和MMP-7的表达,并进行相关分析。结果 VEGF、MMP-7在乳腺导管原位癌和浸润性导管癌中的表达分别为92.00%、88.24%和84.00%、83.82%,显著高于正常乳腺组织的表达47.06%、52.94%(P<0.01)。VEGF、MMP-7的表达与乳腺癌的肿瘤分化程度、临床分期及淋巴结转移有关(P<0.05)。结论 VEGF和MMP-7与乳腺导管原位癌和浸润性导管癌的发生发展相关,并具有协同作用。Objective To investigate the expression and relationship of vascular endothelial growth factor（VEGF） and matrix metalloproteinases -7（ MMP-7 ） proteins in breast ductal carcinoma in situ and infiltrating ductal carcinoma. Methods Immunohistochemical method was used to detect the expression of VEGF and MMP - 7 proteins in 25 breast ductal carcinoma in situ, 68 breast infiltrating ductal carcinoma tissues and 17 normal breast tissue. Results The positive rates of VEGF and MMP -7 in breast ductal carcinoma in situ and breast infiltrating ductal carcinoma tissues were （92. 00%, 88.24% ）and（ 84.00%, 83.82% ）, respectively. They were significantly higher than those in normal group（47.06% and 52.94%, P 〈 0.05 ）. The expression of VEGF and MMP - 7 was significantly correlated with differentiation, TNM stage and lymph node metastasis （ P 〈 0.05 ）. Conclusion VEGF and MMP -7 may all be involved in the carcinogenesis and progression of breast ductal carcinoma. And they maybe play a synergetic role in the process of breast infiltrating ductal carcinoma.

关 键 词：乳腺肿瘤 血管内皮生长因子A 基质金属蛋白酶7 

分 类 号：R737.9[医药卫生—肿瘤]