食管癌全程加速超分割放疗疗效的临床报道  

Therapeutic effects report of whole course accelerated hyperfractionation for esophageal cancer

作　　者：柯柳杨[1] 黄白云[1] 程玉莲[1] 

机构地区：[1]广东省农垦中心医院放疗科,广东湛江524200

出　　处：《中国医学工程》2012年第5期10-11,共2页China Medical Engineering

摘　　要：目的评价食管癌全程加速超分割放射治疗疗效及并发症。方法 60例食管癌随机分为2组:常规分割(Conventionalfractionation,CF)组30例,2Gy/次,1次/d,5次/周,总剂量66Gy,6.6周完成;全程加速超分割(Whole courseaccelerated hyperfractionation,WCAHF)30例,1.5Gy/次,2次/d(间隔不小于6h),10次/周,总剂量66Gy,4.4周完成。结果比较两组1、3、5年局部控制率,WCAHF组明显优于CF组(P<0.05),分别为73.3%、53.3%、43.3%和56.7%、36.7%、26.7%;比较两组1、3、5年生存率,WCAHF组明显优于CF组(P<0.05),分别为70.0%、36.7%、30.0%和56.7%、26.7%、16.7%。WCAHF组急性反应发生率较CF组高,但差异无显著性(P>0.05)。结论食管癌WCAHF放疗能明显提高局部控制率和生存率,不明显增加放射治疗并发症。[ Objective ] To evaluate the therapeutic effects of Whole course accelerated hyperfractionation（WCAHF ） for esophageal cancer. [ Methods ] 60 patients with esophageal cancer, were randomly divided into 2 groups： Conventional fractionation （CF） group-30 cases, once per day, 2 Gy per therapy, 5 therapies per week , the accumulated dose was 66 Gy, and were carried out within 6.6 week; the WCAHF group-30 cases, twice per day, 1.5 Gy per therapy, 10 therapies per week, the accumulated dose was 66 Gy, and were carried out within 4.4 week. [ Results ] The 1, 3, 5 years local control rate of WCAHF group was 73.3%,53.3%,43.3%,and was significantly higher than the CF group, which was 56.7%,36.7%,26.7%, respectively. The 1, 3, 5 years survival rate of WCAHF group was 70.0%,36.7%,30.0%, and was significantly higher than the CF group, which was 56.7%,26.7%,16.7%, respectively. The acute response rate of WCAHF group was higher than the CF group, however, no significant difference was observed. [ Conclusion ] The WCAHF radiotherapy for esophageal carcinoma could elevate the local control rate and survival rate, and meanwhile did not increase the therapeutic reaction and complication of radiation therapy.

关 键 词：食管癌 放疗 全程加速超分割 疗效 

分 类 号：R735.1[医药卫生—肿瘤]