Efficient Synthesis of the Functionalized Spiro[indoline-3,4＇-pyridine] via Four-component Reaction  

作　　者：孙晶 吴群 张藜娟 颜朝国 

机构地区：[1]College of Chemistry&Chemical Engineering,Yangzhou University,Yangzhou,Jiangsu 225002,China

出　　处：《Chinese Journal of Chemistry》2012年第7期1548-1554,共7页中国化学（英文版）

基　　金：Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc.201100657 or from the author.Acknowledgements This work was supported by the National Natural Science Foundation of China （No. 21172189）.

摘　　要：An efficient synthetic procedure for the functionalized spiro[indoline-3,4＇-pyridine] was developed via the four-component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages of this reaction are using common starting material, mild reaction conditions, broad scope of reactants and operational simplicity.An efficient synthetic procedure for the functionalized spiro[indoline-3,4＇-pyridine] was developed via the four-component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages of this reaction are using common starting material, mild reaction conditions, broad scope of reactants and operational simplicity.

关 键 词：spiro compound ISATIN multicomponent reaction electron-deficient alkyne 1 4-DIHYDROPYRIDINE 

分 类 号：O623.624[理学—有机化学] TQ252.4[理学—化学]