精神分裂症患者迟发性运动障碍与血清尿酸浓度关系探讨  

The changes of serum uric acid levels in schizophrenic patients with tardive dyskinesia

作　　者：张喜梅[1] 陈景旭[1] 朱凤艳[1] 石夏明[1] 魏立和[1] 张建新[1] 谭云龙[1] 

机构地区：[1]北京回龙观医院4科,北京100096

出　　处：《国际精神病学杂志》2012年第3期142-144,共3页Journal Of International Psychiatry

摘　　要：目的比较伴有迟发性运动障碍(TD)与不伴TD的精神分裂症患者、正常对照血清尿酸水平,探索尿酸在TD发生机制中可能的作用。方法采用Simpson迟发性运动障碍专用量表进行筛选,共入组TD患者30名(TD组),非TD患者32名(非TD组),健康对照组33名,收集患者性别、年龄、病程、用药时间、体重等相关信息;分别采用阳性和阴性症状量表(PANSS)评定精神病理症状,异常不自主运动量表(AIMS)评定患者TD症状的严重程度;采用全自动生化仪测定三组血清尿酸水平,比较组间差异,并分析TD患者血清尿酸水平与AIMS总分间的关系。结果三组血清尿酸水平(正常组:338.97±81.29umol/l,TD:222.2±69.53umol/l,非TD组:270.46±89.89umol/l)间存在显著差异(F=14.94,P<0.05)。TD患者血清尿酸水平与AIMS评分呈负相关(r=-0.391,P<0.05)。Objective To investigate the possible roles of uric acid in the pathophysiology of tardive dyskinesia（TD） by comparison of serum uric acid levels in schizophrenic patients with TD,without TD and normal volunteers.Methods In present study,30 schizophrenic patients with TD（TD group）,32 without TD（non-TD group） and normal volunteers were recruited by using the Simpson Scale,the general information（e.g.Sex,age,illness duration,weight and so on） was collected.Psychopathological symptoms were assessed by using the positive and negative symptom scale（PANSS）,the severities of TD were assessed by abnormal involuntary movement scale（AIMS）.The levels of uric acid were measured by automatic bio-chemistry analyzer,which were compared in TD group,non-TD group and normal volunteers.The relationship of the serum uric acid levels and the AIMS total scores were analyzed in TD group.Results ① The concentraition of serum uric acid in the normal group（338.97士81.29umol/l）,TD group（222.2±69.53umol/l） and non-TD group（270.46±89.89umol/l） had significant difference（P〈0.05）,② The total scores of AIMS in TD group were negatively correlated with levels of uric acid（r=-0.391,P〈0.05）.Conclusion Uric acid may be involved in the pathophysiological process of TD in schizophrenic patients.

关 键 词：迟发性运动障碍 精神分裂症 尿酸 

分 类 号：R749.3[医药卫生—神经病学与精神病学]